Article type
Year
Abstract
Objective: To evaluate the efficacy,safty and economical values of nucleic acid/nucleotides for clinical nutritional support and immune therapy.
Methods: The following electronic databases were searched: Chinese Biomedicine database (CBM),MEDLINE,EMBASE and SCI. The randomized control trials and sytematic review/Meta-analyses were identified, data were extracted by two reviewers. Applied RevMan 4.1 for statistical analyse.
Results: Forty-six randomized control trials were identified, involving nucleic acids/nucleotides for clinical nutritional support, infant feed, immune therapy. Eighteen randomized trials comparing the use of immunonutrition which comprises nucleotides with standard enteral nutrition in surgical and critical ill patients. Combined analysis indicated that the use of immunonutrition decreases infection events, pool OR is 0.55 95%CI[0.41-0.73] P=0.00004,length of hospitalization, and the cost. Only one trial reported the effects of adding nucleotides to breast milk substitute, but there is no valuable results for clinical practice. Twenty-seven low quality trials compared the use of "immune RNA (iRNA)" with standard methods in patients with hepatitis, carcinoma and burn, combined analysis directed that there are no valid evidences to confirm the value of iRNA. We have not found any available evidences on "nucleic acids nutrients" for alleviate aging progress or improve the life quality of the aged.
Conclusions: Immunonutrition may decrease infection rates, length of hospitalization and cost in surgery and critical ill patients, but we can not affirm the role of the nucleotides in immunonutrition. No evidences support the point of adding nucleotides in breast milk substitute. There should be more studies focus on nucleotides in enteral nutrition support and infants feeding. Also, we can not affirm the role of iRNA in clinical immune regulation therapy, further studies will be needed. There are no available evidences in nucleic acids for caducity prevention and improvement of aging people's health. Consequently, we advise Chinese health officials to enhance the management for applying "nucleic acida nutrients".
Methods: The following electronic databases were searched: Chinese Biomedicine database (CBM),MEDLINE,EMBASE and SCI. The randomized control trials and sytematic review/Meta-analyses were identified, data were extracted by two reviewers. Applied RevMan 4.1 for statistical analyse.
Results: Forty-six randomized control trials were identified, involving nucleic acids/nucleotides for clinical nutritional support, infant feed, immune therapy. Eighteen randomized trials comparing the use of immunonutrition which comprises nucleotides with standard enteral nutrition in surgical and critical ill patients. Combined analysis indicated that the use of immunonutrition decreases infection events, pool OR is 0.55 95%CI[0.41-0.73] P=0.00004,length of hospitalization, and the cost. Only one trial reported the effects of adding nucleotides to breast milk substitute, but there is no valuable results for clinical practice. Twenty-seven low quality trials compared the use of "immune RNA (iRNA)" with standard methods in patients with hepatitis, carcinoma and burn, combined analysis directed that there are no valid evidences to confirm the value of iRNA. We have not found any available evidences on "nucleic acids nutrients" for alleviate aging progress or improve the life quality of the aged.
Conclusions: Immunonutrition may decrease infection rates, length of hospitalization and cost in surgery and critical ill patients, but we can not affirm the role of the nucleotides in immunonutrition. No evidences support the point of adding nucleotides in breast milk substitute. There should be more studies focus on nucleotides in enteral nutrition support and infants feeding. Also, we can not affirm the role of iRNA in clinical immune regulation therapy, further studies will be needed. There are no available evidences in nucleic acids for caducity prevention and improvement of aging people's health. Consequently, we advise Chinese health officials to enhance the management for applying "nucleic acida nutrients".