Article type
Year
Abstract
Objective: To examine the safety and effect of progressive resistive exercise (PRE) interventions on weight, body composition, strength, immunological/ virological, cardiopulmonary, and psychological parameters in adults living with HIV.
Methods: A systematic review of literature on HIV and exercise was performed from 1980 to May 2002 according to the Cochrane Collaboration protocol. Inclusion criteria included randomized controlled trials comparing PRE with no PRE or another exercise treatment modality among adults living with HIV that underwent PRE interventions at least 3 times per week, for a duration of at least 4 weeks. Abstracts were reviewed independently by two investigators to determine study eligibility. Data were extracted from studies that met the inclusion criteria using standardized data extraction forms. Methodological quality of included studies was assessed. Outcomes were analyzed as continuous and dichotomous/binary outcomes. Meta-analysis was conducted with RevMan software using random effects models.
Results: Seven studies met inclusion criteria. Meta-analyses compared outcomes of mean body weight (kg), body composition (mean arm and thigh girth in cm), CD4 count (cells/mm3), and maximum heart rate (beats/min). Main results indicated that PRE was associated with significant increases in body weight and mean arm and thigh girth, non-significant decreases in maximum heart rate, and non-significant increases in CD4 count. Results also indicated potentially clinically important increases for weight and body composition among exercisers compared to non-exercisers. Strength and psychological status were unable to be included in meta-analysis however individual studies showed significant improvements among exercisers.
Conclusions: Performing PRE or a combination of PRE and aerobic exercise at least 3 times per week for at least 4 weeks may lead to clinically significant improvements in weight and body composition for adults living with HIV. PRE may also improve strength and psychological well-being among this population. PRE appears to be safe and may be beneficial for adults living with HIV who are medically stable.
Methods: A systematic review of literature on HIV and exercise was performed from 1980 to May 2002 according to the Cochrane Collaboration protocol. Inclusion criteria included randomized controlled trials comparing PRE with no PRE or another exercise treatment modality among adults living with HIV that underwent PRE interventions at least 3 times per week, for a duration of at least 4 weeks. Abstracts were reviewed independently by two investigators to determine study eligibility. Data were extracted from studies that met the inclusion criteria using standardized data extraction forms. Methodological quality of included studies was assessed. Outcomes were analyzed as continuous and dichotomous/binary outcomes. Meta-analysis was conducted with RevMan software using random effects models.
Results: Seven studies met inclusion criteria. Meta-analyses compared outcomes of mean body weight (kg), body composition (mean arm and thigh girth in cm), CD4 count (cells/mm3), and maximum heart rate (beats/min). Main results indicated that PRE was associated with significant increases in body weight and mean arm and thigh girth, non-significant decreases in maximum heart rate, and non-significant increases in CD4 count. Results also indicated potentially clinically important increases for weight and body composition among exercisers compared to non-exercisers. Strength and psychological status were unable to be included in meta-analysis however individual studies showed significant improvements among exercisers.
Conclusions: Performing PRE or a combination of PRE and aerobic exercise at least 3 times per week for at least 4 weeks may lead to clinically significant improvements in weight and body composition for adults living with HIV. PRE may also improve strength and psychological well-being among this population. PRE appears to be safe and may be beneficial for adults living with HIV who are medically stable.