Objectives: to describe themethod used by the Department of Science and Technology (DECIT) of the Ministry of Health of Brazil to bring policy makers closer to systematic reviews. Methods: the criteria used in selecting systematic reviews strategic projects include larger budgets projects and projects with great pressure for response by public managers. Operationally, for each project selected, five players are involved in the process: (1) the research coordinator; (2) the Ministry of Health’s disease area; (3) the specialized external consultant; (4) DECIT; and (5) inter-institutional financial partnership (Ministry of Science and Technology). The analysis process begins with the coordinators’ presentation of the research proposal, and it is followed by comments and suggestions from the Ministry of Health’s disease area and from the external consultants. In addition to mediating the debate, DECIT intercedes in administrative and juridical issues with the financial partnership. Findings: between 2007 and 2009, eight systematic reviews were followed up, evaluating: statins and fibrates for dyslipidemias (2 projects); anti-cytokines for rheumatoid arthritis (2 projects); antivirals for hepatitis B (2 projects); and enzyme replacement therapy (2 projects). All the projects were modified (to a greater or lesser degree) according to healthcare decision-makers’ interests as the policymakers provided needed information and supplies for conducting the research in the best manner. Conclusions: this process made possible the systematic reviews foster actions carried out by DECIT to be rationalized and better directed. On the other hand, significant project modifications caused difficulties in the administrative procedures. It ought to minimize lapses of time between the research response and decision-making requirements.