Background: To generalize and to systematize the evidence-based decision-making depends not only on knowledge about the best available evidences. This is related to organizational structures and models, physical and political conditions and national legislations that contribute or not to foment that culture, to generate a change of mind and to implement the model. But knowledge is essential for getting this change and it s needed in Cuba. Publication of Cuban clinical trials is dispersed and inconsistent, the editorial policy doesn t adhere to international standards; the production of systematic reviews is missing the same as the formation about it; the contribution to the Cochrane Collaboration is poor, the knowledge of this organization, their information resources and other potentialities are undervalued. Some initiatives in this way have been carried out in Cuba such as the creation of the Cochrane Group, the accessibility to evidence information resources and some hand-searching projects but are not enough. Education and instruction continue being essential premises to guarantee the necessary cognitive component, to convince and to stimulate the transition toward this new dimension in decision-making. Objectives: To encourage evidence based approaches in Cuban health system by providing knowledge and promoting the Cochrane Collaboration. Methods: A research-development project was proposed by the Coordinating Centre of clinical trials and approved by Ministry of Health. It s related to the creation of a national network for promoting the evidence and the Cochrane Collaboration, designing information services and educational resources and developing continuing education programmes. Results: Till now are facts: the creation of the first Cuban website devoted to information about theory, methodology and practice in the use and generation of evidence. The website includes a column for the promotion of the Cochrane Collaboration as well as educational lessons and Supercourse, and information resources. A national group of leaders in the field has been created and has engaged the former Cuban Cochrane Group in order to stimulate the work of that organization in the country. Four foreign experts have already been integrated as partners for fomenting the exchange of experiences. A new project for hand-searching has been recalled with the Iberoamerican Cochrane Centre and a policy for it has been proposed and approved by the CCIb. A central web-database of previous and current hand-searched trials is designed to improve the access and contribute to develop systematic reviews in prioritized health topics in Cuba and others developing countries. A continuing education e-learning programme which includes topics such as evidence-based medicine methodology, systematic reviews, meta-analysis was designed. Some motivational seminars and oral communications in national events have been developed for introducing related topics and promoting information sources. A combined work has settled down with medical sciences journals tomodify their editorial policy toward the endorsement to international standards. Strategies for promoting and extending the Cuban Registry of Clinical Trials are planned. Conclusions: These Cuban initiatives increase the use of available evidences; they enlarge the knowledge about it; they stimulate the clinical trials publication, improve their quality, minimise the biases and promotes the development of systematic reviews when they are relevant for Cuba and other developing countries. The network seeks to be a reference point on the CC through giving conferences, chats, trainings and other promotional materials. It s now a priority: motivational activities and diagnosis of knowledge and attitudes on the evidence to know how to direct motivation. A diagnostic questionnaire has been designed and validated by experts and it has been applied in a sample of institutions. Another priority is to promote the production of evidence and influence the editorial policy of the Cuban medical journals. This last issue is related to my dissertation topic. Now we are preparing a workshop on international requirements and standards in the publication of clinical trials for publishers and editors of medical journals.