Efficacy of Steroids in esophagic burns caused by caustics in children

Article type
Authors
Mora-Magana I1, Perez-fernandez L2, Castillo-Baires J3
1Methodology of Research, Instituto Nacional de Pediatria, Mexico
2Pneumology and Tohrax Surgery Deparment, Instituto Nacional de Pediatria, Mexico City, Mexico
3San Salvador, El Salvador
Abstract
Background: Caustics produce injuries such as burns. It may cause inflammatory fibrosis injuries and esophagus stenosis permanently. Steroids use is controversial in these cases. Immediate cortisone use after the event in laboratory species may relief granulomas. This is the reason why it is highly recommended to use it. Other authors describe that steroids do not get any relief in esophagus morbidity. This is the main dilemma in these patients. Objectives: Assess the therapeutic efficacy of steroids in children whit caustic injury of the esophagus and its stenosis. Types of Studies: Randomized Controlled Clinical Trials and Quasi randomized with steroids(prednisone, hidrocortisone, metilprednisolone and dexametasone) in children who swallowed caustics. Patients: Children (1mo thru 18yr) who swallowed caustics Quality of Methodology: At least two reviewers independently assessed clinical trial quality with CASP (Critical Apraisal Skilss Programme) for clinical trials, and with Jadad s scale. Results: 18 papers were identified, only 2 were included: Anderson 1990 and Bautista 1996. These papers had 96 patients. There was not disagreement in inclusion. Author s Conclusions: Steroids show a relevant effect in children who swallowed caustics. Bautista has many variables included in analysis while Anderson does not. In all cases antibiotic therapy is mandatory in high doses. 3rd degree esophagic injuries cause stenosis and stricture more frequently than others.