Background: The scope of the Cochrane Collaboration recently has been extended from prevention and treatment of diseases to public health, health decision-making, and areas beyond the medical health field. The population served by the collaboration has thus been extended from health professionals to policy makers, even all health consumers. The Cochrane Collaboration has established partnerships with governmental health departments, the World Health Organization, the Campbell Collaboration, and other organizations. The Chinese Cochrane Centre has also established wide-ranging strategic cooperation with related institutes and organizations. Objective: To establish the Chinese Clearinghouse for Evidence-Based Practice and Policy (CCEBPP) for improving the quality and using efficiency of research evidence on social work practice and related human services. Methods: A project was introduced from abroad for dissemination and training of the knowledge related to evidence-based practice and policy. Then, evidence addressing specific problems identified from China was produced and practiced in these fields. Results: Chinese Cochrane Centre had joined hands with USC School of Social Work, Hamovitch Center, for establishing CCEBPP. The plan included two steps. For the first step, a working group and a website would be established; the related contents of the California Evidence-Based Clearinghouse for Child Welfare would be translated and introduced into China; as well as a series of workshops would be held. For the second step, an advisory committee and a scientific panel would be established; a series of programmes addressing the Chinese problems would be identified for local evidence production, practice and dissemination. Conclusions: The CCEBPP will become an important supplement of the Chinese Cochrane Centre. It will be helpful for improving the quality and using efficiency of research evidence on social work practice and related human services.