Background: The US Satellite of the Cochrane Eyes and Vision Group (CEVG), the CEVG US Project (CEVG@US), has been funded since 2002 by the National Eye Institute, National Institutes of Health (NIH) and was recently awarded funding for an additional five years. Objectives: To highlight the progress of CEVG@US from 2002 to 2009. Methods: CEVG@US supports US-based review authors through consultations with methodologists and educational workshops. US handsearchers identify reports of controlled clinical trials in eye and vision journals and conference proceedings. The CEVG@US also conducts methodological research on identification of evidence gaps and systematic reviews. Results: In addition to contributing to over 26% of published CEVG reviews and providing educational opportunities for more than 1,000 individuals, CEVG@US has established key partnerships with professional associations including the American Academy of Ophthalmology and American Optometric Association which enhance the quality of reviews and contribute to the translation of evidence to the appropriate audience. US handsearching efforts have contributed over 8,500 CCTs (350 journal-conference years) to the CEVG specialized register. CEVG@US has begun to convert the register from being citation- based to study-based, and will include international standard diagnostic and intervention coding to facilitate retrieval by healthcare providers. CEVG@US was awarded a grant through the 2007 Cochrane Prioritisation Fund, on using practice guidelines to determine systematic review priorities. This project provided the foundation for a recent award from the NIH to assess the effectiveness of medical interventions for primary open-angle glaucoma using Bayesian mixed treatment comparison meta-analysis. Conclusions: The CEVG@US has supported the aims of CEVG and strengthened the contribution of US vision researchers and authors through multiple avenues. The regional satellite model is an approach other Cochrane entities may wish to implement.