Background: Injuries are the leading cause of childhood death in most countries; steep social gradients exist in mortality and morbidity. The majority of pre-school injuries occur in the home but the science of implementing research into practice in the field of injury prevention has received little attention. Objectives: To describe key barriers and facilitators when implementing health promotion and injury prevention interventions. Methods: We used the papers included in the Cochrane systematic review of home safety education and provision of safety equipment for injury prevention (Kendrick 2007) that was updated in 2010 using the same search and review strategy. Each paper was screened to ensure that children under 5 years were included. Subsequently, they were included if they specified two of the following criteria: detail of the intervention, process measures and/or information about barriers and facilitators. Two authors independently reviewed each paper and extracted data. Framework analysis was used: an iterative process whereby the initial themes were identified after the first 10 papers had been reviewed jointly, four further themes were identified after 25 papers. Previous summaries were then coded for the new themes. Results: 42 papers were included. Seven key barriers and seven facilitators were identified in the implementation of health promotion and injury prevention interventions. The barriers include the complexity of the interventions, length of follow-up, cultural barriers, contamination of controls, physical barriers, behavioural barriers and deliverer constraints. Facilitators relate to: the approach used, whether the message was focused, minimal changes were involved, characteristics of the deliverer, accessibility to equipment, behaviour change and whether incentives were built-in. Conclusions: Barriers and facilitators will be used to develop an Injury Prevention Briefing which will be evaluated in a randomised-controlled trial to be undertaken in the community in the UK.