Background: Health systems in low- and middle-income country (LMIC) settings face major challenges from the high burden of infectious diseases and the growing burden of chronic illnesses, combined with severely constrained resources. There is therefore a need to identify priorities for, and conduct, systematic reviews of interventions relevant to health system questions in these settings, and to build capacity to prepare and support the use of relevant systematic reviews. The Norwegian Satellite of the Effective Practice and Organisation of Care Group (EPOC) was established to support the production of Cochrane reviews that address questions related to health systems in low- and middle-income countries. Objectives: To describe the experiences of the Norwegian EPOC satellite to identify priorities and build capacity to develop reviews on health systems questions relevant to LMIC. Methods: We review our experiences in: Establishing linkages with organisations working on health system questions; recruiting and supporting review authors from LMIC; facilitating the production of reviews on questions relevant in these settings; and identifying priority topics bymapping the gaps where good quality up-to-date reviews are not available. Results: Currently, review authors from 12 countries have developed or are developing Cochrane reviews. These countries are Kenya, Uganda, Nigeria, South Africa, Tanzania, Cameroon, Bangladesh, China, India, Chile, Argentina and Iran. These reviews address questions about health insurance, health financing and human resources for health, among others. Collaborations with organisations like the Norwegian Agency for Development Cooperation (Norad), the Alliance for Health Policy and Systems Research (AHPSR), the World Health Organization, the Evidence-Informed Policy Network (EVIPNet), the South Asian Cochrane Network and the South African Cochrane Centre have been established. A preliminary list of priority topics for reviews has been generated and will continue to be updated. Conclusions: A focussed effort by The Norwegian satellite of the EPOC group has facilitated preparing, updating and making accessible reviews to inform decisions on how to provide effective, efficient and equitable health services in LMIC.