Background: In 2004, the Institute forWork & Health (IWH) launched a prevention systematic review initiative. Funded by the Workplace Safety and Insurance Board (WSIB) of Ontario, this pilot built on the existing experience at IWH which has been conducting clinical reviews since 1994, and houses the Cochrane Back Review Group (CBRG). The prevention review initiative was undertaken in response to a concern raised by non-research partners in the prevention system that there was limited accessible evidence about the effectiveness of interventions for protecting workers health. Objectives: This presentation will describe a systematic review program in the area of occupational health and safety. Methods: Aspects of the four year pilot will be explored. We will focus on the description of the IWH Stages of the systematic review and challenges and benefits of our approach. We will elaborate upon the adaptations required from the clinical reviews process from CBRG and the reasons for each adaptation. Overall challenges of program initiation and sustainability will also be assessed. Results: To date the program has delivered 17 reports to the WSIB and the broader Occupational Health and Safety audiences, held 32 stakeholder consultations and meetings, produced nine peer-reviewed publications and given 32 conference presentations. We have published three methods papers from our experiences from this pilot project that describe adaptations. Conclusions: This four-year pilot produced systematic reviews of the effectiveness of interventions to prevent workplace injury, illness and disability. Conducting reviews in the area of occupational health and safety literature requires significant adaptation of the methods used to conduct clinical reviews.