Background: Recent scientific meetings such as the joint Cochrane Collaboration & Evidence based Health Care (EBHC) conference in Vellore have highlighted the importance of raising awareness of medical students in the concept of EBM. Early adoption by students could possibly be further enhanced by their involvement with some of the activities undertaken by the Cochrane Collaboration. To date very limited research has been carried out on the knowledge and attitudes towards EBM among medical students and Interns. Objective: Our study intends to survey the knowledge and attitudes towards EBM among medical students and Interns at Manipal University, India. Methods: Final year medical students and interns completed a previously piloted 14-question survey. MCQ s included: awareness of the components of EBM, the hierarchy of evidence, barriers to the practice of EBM and familiarity with healthcare databases and the Cochrane Library. Results: Eighty percent of respondents were final year medical students and the remainder were Interns. A number of the participants had attended a course/workshop on EBM and all were keen to learn more about the concept and the work of the Cochrane Collaboration. Generally respondents were familiar with the hierarchy of evidence and most were aware of The Cochrane Library. The majority of the respondents felt that the lack of time was the main barrier to the practise of EBM but agreed that if resources were readily available they would be willing to acquaint themselves with the concept. Conclusion: Overall there was a positive attitude and fair knowledge level amongst participants towards EBM, the Cochrane symposium for students was positively contributory towards this. The final study will further examine the correlation between different grades of education and the awareness about Cochrane Collaboration.