Background: Achieving the millennium development goals in low and middle-income countries (LMIC) will depend on policymakers accessing the best evidence about services that work, and integrating this evidence into their national health systems. With this in mind, researchers and policymakers from Africa, Europe, and North and South America came together to form SUPPORT (SUPporting Policy-relevant Reviews and Trials); with the aim of promoting evidence-informed policymaking in LMIC. Objective: To present SUPPORT’s objectives and achievements. Methods: SUPPORT set out to summarise systematic reviews on priority interventions for reducing maternal and child mortality as well as health systems arrangements for their cost-effective delivery; and develop tools to support the use of research evidence to inform policy decisions and the conduct of pragmatic trials when reliable evidence is lacking. Results: From 2006 to 2010 SUPPORT produced more than 200 summaries of reviews with discussion of the relevance of findings to LMIC, the Policymaker Tools (STP), Trial-Management Tool (TMT) and Trial-Funding Tool (TFT); conducted workshops for over 280 policymakers in Africa and South America; and developed both a trial-management and systematic review course. STP is a series of articles that address four areas: supporting evidence-informed policymaking; identifying needs for research evidence on problem clarification, options framing, and implementation planning; finding evidence to inform these steps; and going from evidence to decisions. TMT and TFT are packages of resources to improve trial management and access to support on trial funding for LMIC researchers respectively. The policymaker workshops empower policymakers to become informed users of research-based evidence. Conclusion: SUPPORT provides a model of how researcher-policymaker partnerships and cross-continental linkages can be used to improve the use of reliable research evidence in policymaking and to fill in gaps where there is lack of reliable evidence. SUPPORT materials are available free on the SUPPORT website (www.support-collaboration.org).