Background: In late March and early April 2009, an outbreak of H1N1 influenza A virus infection was detected in Mexico, with subsequent cases observed in many other countries, including the China. The most timely translation and dissemination evidence from Cochrane library and other evidence based resources were vital for doctors in rural areas. Objective: Assessing the effectiveness of sending Influenza A (H1N1) evidence through the Short Message Service (SMS) to the doctors in rural areas in China. Methods: From 10th November to 29th December, we sent 30 short messages (1,600 words) about etiology, diagnosis, treatment, prevention and vaccines on Influenza A (H1N1) evidence at seven P. M. every Tuesday and Friday to 114 doctors of seven Township Health Centers in Gansu province. And then we conducted a telephone survey of these doctors at 30th December. Results: A total of 89 doctors answered (response rate 67.8%). 86 doctors (96.6%) received our short messages, 47 doctors (54.7%) said the short messages helped them a great deal (reliable, useful and readable), and 83 doctors (96.6%) said they expected to keep on receiving our short messages. Conclusions: Short Message Service seemed to be a good way to disseminate best evidence especially for pandemic. And it can be used in rural area in developing countries for the fast spread, low cost and convenient reading.