Background: Interaction between researchers and policymakers related to knowledge transfer has been motive of review and mythological analysis. Objectives: To describe two examples of synthesis of evidence in response to government requirement Methods: A systematic approach was used to search, retrieve and synthesize relevant evidence in response to questions formulated by policymakers of the national Ministry of Health. Electronic searches in specific databases (MEDLINE, LILACS and DARE/Cochrane, etc), meta-searchers (Clinical Excellence) and hand-searching were preformed. Study selection was done in two phases: 1. Population, intervention and outcome criteria were applied by two reviewers to select eligible studies; 2. Cochrane Effective Practice and Organization of Care Review Group evaluation criteria were applied by one reviewer in order to select included studies. Evidence was synthesized and presented in a friendly format Results: Case 1 community participation in dengue control; Question; What is the effectiveness and/or cost-effectiveness in the short, medium and long term of community based strategies either isolated or combined with other strategies to prevent and/or control of dengue vector? 1563 references were recovered. Of these, 135 studies met the eligibility criteria and 77 were potentially relevant to the report: 3 studies were systematic reviews (synthesize 62 of 77 retrieved articles), 3 economic evaluations and 10 were not included in systematic reviews Case 2 2009 H1N1 influenza in pregnancy Questions a) Are antiviral drugs safe and effective for the prevention/treatment of influenza in pregnant women? b) What is the effectiveness and safety of influenza type A (H1N1) in pregnant women? 200 references were retrieved, of which 115 met the eligibility criteria. Of these, 98 articles were included for analysis. Two brief reports containing key messages were presented to policymakers. Conclusions: Rapid response can be developed in a clear, transparent and systematic way at the request of policymakers to help informed decisions.