Setting priorities for comparative effectiveness research on the management of primary angle closure (PAC): A survey of Asia-Pacific clinicians

Article type
Authors
Yu T1, Li T1, Puhan M1, Dickersin K1
1Johns Hopkins Bloomberg School of Public Health, Epidemiology
Abstract
Objective: To set priorities for new systematic reviews on the management of primary angle closure (PAC), using clinical practice guidelines and a survey of clinicians from the Asia-Pacific region.

Methods: We restated the American Academy of Ophthalmologyás Preferred Practice Patterns (AAO PPPs) recommendations for management of PAC into 42 answerable clinical questions. We asked registrants at the Asia-Pacific Joint Glaucoma Congress 2010 in Taipei to rate the importance of having an answer to each question for good patient care, using a Likert-type scale from 0 (not important at all) to 10 (highly important). To assess understanding, we first asked two knowledge assessment questions about the survey objective, and allowed retries if the response was not correct. Respondents were randomized to one of two questionnaires, which had different orders of the same questions. The survey and instructions were in English.

Results: 175 agreed to participate in the survey, 132 responded (75.4% response rate), and 96 completed the questionnaire (54.9% usable response rate). For those who responded but did not complete, half stopped after the two knowledge assessment questions. Of 96 who completed, only 29 (30.2%) correctly answered the knowledge assessment questions on the first attempt. The distribution of importance ratings pooled from all questions was skewed to high importance (mean = 6.92; median = 8). The order of questions affected the importance ratings (Figure1). We considered clinical questions to be of priority if at least 75% of respondents gave ratings above 5.

Conclusions: Understanding the survey purpose and questions affected our response rate, and question order affected question importance rating. We identified a list of clinical questions on the management of PAC for which research should be prioritized. Where evidence does not exist, primary research and systematic reviews should be initiated to address these questions.