Background: The National Collaborating Centre for Women’s and Children’s Health (NCC-WCH) is contracted to produce clinical guidelines for use in the UK National Health Service (NHS). These guidelines provide specific granular evidence and/or consensus-based recommendations for the care of women and children using the NHS. Because of this, our recommendations may not be translated easily into clinical practice in other countries.Cochrane reviews adopt a more 'holistic’ approach by including studies from all countries and writing 'Implications for practice’ based on the findings of the review. However these 'Implications for practice’ are not always directly relevant to both developed and developing countries, and an alternative approach might be to use sub-group analyses to inform specific 'Implications for practice’ for different countries. This should help promote global improvements in the quality of healthcare through the increased use of more context-specific 'Implications for practice’ in Cochrane reviews.

Objectives: To evaluate how the results of systematic reviews, and the ensuing 'Implications for practice’ and recommendations, are affected by the inclusion or exclusion of evidence from different countries.

Methods: We identified systematic reviews, in NCC-WCH guidelines, that included evidence from all countries, and then performed sub-group analyses to examine the effect of including only evidence from developed or developing countries. We then examined the potential implications for creation of more context-specific practice recommendations.

Results: Results will be presented at the Colloquium.

Conclusions: Conclusions will be presented at the Colloquium.