Article type
Year
Abstract
Background: Essential medicine for common disease is important for primary health care.
Objectives: To get an evidence-based evaluation and selections of essential medicine for treatment of children’s fever and adult stomach flu caused by common cold.
Methods: Using the standards, methods and processes for evidence-based evaluation and selection of essential medicine established in Series 2 to make an evidence-based evaluation and recommendations of relevant medicine. Software such as Review Manager and GRADE profiler were used for processing data and evaluating evidence quality.
Results: Twelve guidelines were included. Compared with paracetamol solution in children, four RCTs (very low quality evidence)showed that ibuprofen suspension had the similar antipyretic effect on children catching cold, the pooled relative risk (RR)of its antipyretic effect within 6 hours was RR 1.48, 95% CI (0.66, 3.30); The main side effects were gastrointestinal adverse reactions and profuse sweat, [RR1.23 (0.72, 2.11)]; the cost was 1.93 daily; It had a better applicability for oral administration without supervision. Compared with ibuprofen suspension in children, three RCTs (low quality evidence) indicated that 30 minutes, 1 hour after taking medicine, the antipyretic effect of acetaminophen suppositories was both better [MD = −0.16◦C and −0.19◦C, 95% CI (−0.21,−0.11) and (−0.28,−0.10) respectively]. The main side effects were discomfort caused by stimulus to anus rash profuse sweat [RR = 1.84, 95% CI (0.62, 5.44)] the cost was 0.9 daily to treat children with fever, It had a good applicability for transanal administration. Compared with motilium, five RCTs low quality evidence indicated that the Huoxiang Zhengqi capsules had a better effect for treating gastrointestinal symptoms, [RR = 3.09, 95% CI(2.01, 4.75)]; one RCT (median evidence quality showed that the total effective rate of the medicine treating gastrointestinal symptoms caused by common cold was 98.06% without adverse effects; the cost was 0.63 daily; It had a good applicability for oral administration.
Conclusions: The essential medicines are recommended: I. Ibuprofen suspension, 2 g/100 mL (Strongly recommended), used in children. II. Acetaminophen suppositories, 0.1 g/suppository (Strongly recommended), used in children. III. Huoxiang Zhengqi capsules, 0.3 g/capsule (Strongly recommended), used in adults.
Objectives: To get an evidence-based evaluation and selections of essential medicine for treatment of children’s fever and adult stomach flu caused by common cold.
Methods: Using the standards, methods and processes for evidence-based evaluation and selection of essential medicine established in Series 2 to make an evidence-based evaluation and recommendations of relevant medicine. Software such as Review Manager and GRADE profiler were used for processing data and evaluating evidence quality.
Results: Twelve guidelines were included. Compared with paracetamol solution in children, four RCTs (very low quality evidence)showed that ibuprofen suspension had the similar antipyretic effect on children catching cold, the pooled relative risk (RR)of its antipyretic effect within 6 hours was RR 1.48, 95% CI (0.66, 3.30); The main side effects were gastrointestinal adverse reactions and profuse sweat, [RR1.23 (0.72, 2.11)]; the cost was 1.93 daily; It had a better applicability for oral administration without supervision. Compared with ibuprofen suspension in children, three RCTs (low quality evidence) indicated that 30 minutes, 1 hour after taking medicine, the antipyretic effect of acetaminophen suppositories was both better [MD = −0.16◦C and −0.19◦C, 95% CI (−0.21,−0.11) and (−0.28,−0.10) respectively]. The main side effects were discomfort caused by stimulus to anus rash profuse sweat [RR = 1.84, 95% CI (0.62, 5.44)] the cost was 0.9 daily to treat children with fever, It had a good applicability for transanal administration. Compared with motilium, five RCTs low quality evidence indicated that the Huoxiang Zhengqi capsules had a better effect for treating gastrointestinal symptoms, [RR = 3.09, 95% CI(2.01, 4.75)]; one RCT (median evidence quality showed that the total effective rate of the medicine treating gastrointestinal symptoms caused by common cold was 98.06% without adverse effects; the cost was 0.63 daily; It had a good applicability for oral administration.
Conclusions: The essential medicines are recommended: I. Ibuprofen suspension, 2 g/100 mL (Strongly recommended), used in children. II. Acetaminophen suppositories, 0.1 g/suppository (Strongly recommended), used in children. III. Huoxiang Zhengqi capsules, 0.3 g/capsule (Strongly recommended), used in adults.