Background: Evidence about benefits and harms of interventions is essential but not sufficient for making healthcare decisions. Additional factors must be considered, including values (the relative importance of benefits and harms), resource use, equity, and the intervention’s acceptability and feasibility. These factors are not always considered in a balanced or transparent way.

Objectives: DECIDE frameworks aim to help people systematically think through each factor (criterion) that is relevant for a particular recommendation or decision. These include clinical recommendations, coverage decisions, and health system and public health recommendations and decisions.

Results and Conclusions: Each framework includes a set of criteria, judgments about each criterion and the evidence informing those judgments. The frameworks enable people to systematically consider all the important factors leading to a recommendation or decision. Their conclusion, with the evidence and judgments leading to it, becomes transparent. The frameworks are being developed by DECIDE (a project funded by the European Union’s 7th Framework Programme) and the GRADE Working Group.