Background: A significant proportion of neonatal deaths are attributable to birth asphyxia, which is also responsible for stillbirths. Newborn resuscitation is a cornerstone of modern neonatology, but it is not available for the majority of newborns who are born in low and middle income countries due to poorly staffed and equipped health facilities and births at home, where birth attendants may lack skills. Objectives: To assess the feasibility and impact of community based approach of neonatal resuscitation in perinatal depression. Methods: We conducted a systematic review of randomized controlled trials, quasi experimental studies and observational studies to estimate the effect. We used a standardized abstraction and grading format and performed meta-analyses for all the relevant outcomes using the standard Cochrane guidelines. Results: Implementing a community and outreach home-based package for immediate newborn assessment and basic resuscitation of birth asphyxia through lay workers results in a reduction in perinatal mortality (risk ratio (RR): 0.89 [95% confidence interval (CI): 0.80 to 0.98] 5 studies), asphyxia specific mortality (RR: 0.37 [95% CI: 0.17 to 0.78] 1 study) and neonatal mortality (RR: 0.74 [95% CI: 0.59 to 0.92] 4 studies), while has non-significant impacts on stillbirth (RR: 0.93 [95% CI: 0.81 to 1.06] 6 studies). It also led to an increase in the rates of resuscitation performed (RR: 1.28 [95% CI: 0.86 to 1.91] 3 studies). Conclusions: Community based resuscitation is an effective strategy to save newborn lives who do not have access to specialized care.