Article type
Year
Abstract
Background: colorectal cancer (CRC) is the third most commonly diagnosed cancer and the fourth most common cause of cancer death worldwide. Knowledge translation and implementation of the current best available evidence into clinical practice and public health is crucial in CRC, as well as for other effective diagnoses and treatment. Diagnosis and treatment of early colorectal cancer (stages I and II) has been approved as one of the topics of pilot national guidelines in the Czech National Guidelines Project based on epidemiological analysis.
Objectives: this clinical practice guideline is dealing with the best available diagnostic and therapeutic approaches in early colorectal cancer which will be implemented in the Czech Republic health system.
Methods: this guideline was developed according to 'Czech National Methodology for Clinical Practice Guidelines development', which is based on the GRADE methodology. Primary inclusion and exclusion criteria of the guideline objectives were specified in PICO format (Participants, Intervention, Comparator, Outcomes). Secondary, there was assessed if the guideline was actual and used standardized methodological approach based on the GRADE. Search of existing guidelines was provided in 23 relevant guideline and systematic review databases and sources using following keywords: colorectal cancer, colorectal neoplasm/s, colorectal carcinoma/s, colorectal tumor/s, colonic neoplasm/s, rectal neoplasm/s, diagnosis, treatment, guideline/s, recommendation/s. Critical appraisal of all relevant guidelines was done using a standardized instrument AGREE 2 (Appraisal of Guidelines for Research and Evaluation).
Results: based on the search of all relevant sources, we identified 35 potentially relevant guidelines. After retrieval and critical appraisal of them, there was only one recent, high-quality clinical practice guideline suitable for adaptation for the Czech healthcare system using standardized instrument ADAPTE S3-Leitlinie – Kolorektales Karzinom (021/0070L). All members of the guideline team and also the multidisciplinary panel agreed to “adopt” which means to accept all recommendation from the German guideline without any modifications. Several recommendations were based on Cochrane systematic reviews. Evidence-based recommendations were formulated and presented using most of the GRADE approach. Consensus recommendations were based on robust and a transparently documented Delphi method in a report of the German guideline.
Conclusions: this clinical practice guideline was developed within the 'Czech National Guidelines Project'. Following public approval by professional community, and relevant stakeholders including the Ministry of Health, the guideline will be implemented into practice.
Patient or healthcare consumer involvement: the Chairman of the Patient Council - part of the Ministry of Health - was involved in the process of developing this guideline as a member of the Guarantee Committee within the 'Czech National Guidelines Project'.
Objectives: this clinical practice guideline is dealing with the best available diagnostic and therapeutic approaches in early colorectal cancer which will be implemented in the Czech Republic health system.
Methods: this guideline was developed according to 'Czech National Methodology for Clinical Practice Guidelines development', which is based on the GRADE methodology. Primary inclusion and exclusion criteria of the guideline objectives were specified in PICO format (Participants, Intervention, Comparator, Outcomes). Secondary, there was assessed if the guideline was actual and used standardized methodological approach based on the GRADE. Search of existing guidelines was provided in 23 relevant guideline and systematic review databases and sources using following keywords: colorectal cancer, colorectal neoplasm/s, colorectal carcinoma/s, colorectal tumor/s, colonic neoplasm/s, rectal neoplasm/s, diagnosis, treatment, guideline/s, recommendation/s. Critical appraisal of all relevant guidelines was done using a standardized instrument AGREE 2 (Appraisal of Guidelines for Research and Evaluation).
Results: based on the search of all relevant sources, we identified 35 potentially relevant guidelines. After retrieval and critical appraisal of them, there was only one recent, high-quality clinical practice guideline suitable for adaptation for the Czech healthcare system using standardized instrument ADAPTE S3-Leitlinie – Kolorektales Karzinom (021/0070L). All members of the guideline team and also the multidisciplinary panel agreed to “adopt” which means to accept all recommendation from the German guideline without any modifications. Several recommendations were based on Cochrane systematic reviews. Evidence-based recommendations were formulated and presented using most of the GRADE approach. Consensus recommendations were based on robust and a transparently documented Delphi method in a report of the German guideline.
Conclusions: this clinical practice guideline was developed within the 'Czech National Guidelines Project'. Following public approval by professional community, and relevant stakeholders including the Ministry of Health, the guideline will be implemented into practice.
Patient or healthcare consumer involvement: the Chairman of the Patient Council - part of the Ministry of Health - was involved in the process of developing this guideline as a member of the Guarantee Committee within the 'Czech National Guidelines Project'.
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