StemCreDB: stem cell clinical research database platform based on systematic review

Article type
Authors
Yim HW1, Jeong H1, Oh I1, Kim N1
1College of Medicine, The Catholic University of Korea
Abstract
The StemCreDB (stem cell clinical research database) is designed both to help developers to establish a developmental strategy and regulatory authorities to set up a regulatory policy in advance by providing extensive information on clinical development trends initiated by industry. We constructed the StemCreDB database by a systematic search in Pubmed for original articles and review articles to be stored in the database. We are updating our literature reviews on new research articles quarterly.

The database consists of three categories: research milestone, article search, and interactive visual analysis.
Firstly, stem cell research milestone shows the main events in research, summarized in chronological order in each disease. Currently, the published research articles on cardiovascular, bone, neurology, autoimmune, gastrointestinal diseases, pulmonary disease, and urinary disease are being collected. Secondly, to date, 1717 stem cell-based clinical articles have been uploaded in the StemCreDB. Data search is available in terms of various study categories, including study object, phase, study design, stem cell type, route of delivery, follow-up period etc. Thirdly, interactive visual analysis helps to discover information in the data that is not readily apparent in simple graphing. This tool will visualize detailed analysis results obtained from multiple disease groups at one view as well as a single disease group. If you select a certain data bar of your topic of interest, subgroup analysis results for the selected group will automatically appear.

Through this database, we hope to help stem-cell researchers have easy access to the stem cell-based published researches related to pharmacodynamics, pharmacokinetics, dose finding studies, clinical efficacy, clinical safety, and biovigilance, which are essential to develop state-of-the-art stem-cell based materials.
All the data in stemcreDB can be searched by visiting the website stemcredb.net.

Acknowledgement: this research was supported by a grant (18172MFDS182) from the Ministry of Food & Drug Safety in 2018.