Article type
Year
Abstract
Background: Malaria is one of the serious global problems of our time. Artemisinin-based combination therapies (ACTs) have contributed substantially to the reduction in the global burden of malaria. However, Artemisinin and partner-drug resistance in Plasmodium falciparum are major threats to malaria control and elimination. Recently, the Triple artemisinin-based combination therapies were found to provide effective treatment and delay emergence of antimalarial drug resistance.
Objectives:The objective of this systematic review and network meta-analysis is to assess the current latest evidence on Artemisinin-based combination therapies for malaria: a systematic review and network meta-analysis as comprehensive as possible.
Methods: The Cochrane Library, EMBASE, PubMed and Web of science were searched from the earliest publication date available. We included randomized controlled trials comparing artemisinin-based combination therapies (ACTs) for malaria. We also screened the reference lists of relevant reviews. No language restrictions were applied. Two authors independently included studies, extracted data, and assessed risk of bias. The weighted mean difference (WMD) is used as the effect size for the continuous variables. Summary risk ratios (RR) with 95% confidence intervals (CI)were presented if the results were binary variables.
Results: Final results will be available by the time of the Cochrane Colloquium.
Conclusions: This systematic review and network meta-analysis will provide efficacious, well tolerated, and safe choice of artemisinin-based combination therapies (ACTs) for malaria. Findings of this project will present simply and concisely for informed decision-making.
Patient or healthcare consumer involvement: No
Objectives:The objective of this systematic review and network meta-analysis is to assess the current latest evidence on Artemisinin-based combination therapies for malaria: a systematic review and network meta-analysis as comprehensive as possible.
Methods: The Cochrane Library, EMBASE, PubMed and Web of science were searched from the earliest publication date available. We included randomized controlled trials comparing artemisinin-based combination therapies (ACTs) for malaria. We also screened the reference lists of relevant reviews. No language restrictions were applied. Two authors independently included studies, extracted data, and assessed risk of bias. The weighted mean difference (WMD) is used as the effect size for the continuous variables. Summary risk ratios (RR) with 95% confidence intervals (CI)were presented if the results were binary variables.
Results: Final results will be available by the time of the Cochrane Colloquium.
Conclusions: This systematic review and network meta-analysis will provide efficacious, well tolerated, and safe choice of artemisinin-based combination therapies (ACTs) for malaria. Findings of this project will present simply and concisely for informed decision-making.
Patient or healthcare consumer involvement: No