Article type
Year
Abstract
Background:
Previous study had found a dose-response relation between alcohol and risk of dementia. Mild cognitive impairment (MCI) is a cognitive state falling between normal aging and dementia. However, the relation between alcohol intake and risk of MCI as well as progression to dementia in people with MCI (PDM) remained unclear.
Objectives:
We aimed to synthesize available evidence and clarify the relation between alcohol intake and risk of MCI as well as PDM.
Methods:
We searched electronic databases consisting of PubMed, EMBASE, Cochrane Library, and China Biology Medicine disc (CBM)) from inception to October 1, 2019. Only prospective studies that reported at least three level of alcohol exposure were included. Categorical meta-analysis was used for quantitative synthesis of the relation between light, moderate and heavy alcohol intake with risk of MCI and PDM. Restricted cubic spline and fixed-effects dose-response models were used for dose-response analysis.
Results:
Six prospective cohort studies including 4,244 individuals were finally included. We observed an unstable linear relation between alcohol intake (drinks/week) and risk of MCI (P-linear=0.0396). It suggested that a one-drink increment per week of alcohol intake was associated with an increased risk of 3.8% for MCI (RR, 1.038; 95%CI: 1.002-1.075). Heavy alcohol intake (>14 drinks/week) was associated with high risk of PDM (RR=1.76; 95%CI: 1.10-2.82). And we found a nonlinear relation between alcohol intake and risk of PDM. Drinking more than 16 drinks/week (P-nonlinear=0.0038, HR=1.42; 95%CI: 1.00-2.02), or 27.5 grams/day (P-nonlinear=0.0047, HR=1.46; 95%CI: 1.00-2.11) would increase the risk of PDM.
Conclusions:
There was a nonlinear dose-response relation between alcohol intake and risk of PDM. Excessive alcohol intake (>16 drinks/week, or 27.5 grams/day) was associated with higher risk of PDM. And there was an unstable linear dose-response relation between alcohol intake and risk of MCI.
Patient or healthcare consumer involvement:
There was no patient or healthcare consumer in this project.
Previous study had found a dose-response relation between alcohol and risk of dementia. Mild cognitive impairment (MCI) is a cognitive state falling between normal aging and dementia. However, the relation between alcohol intake and risk of MCI as well as progression to dementia in people with MCI (PDM) remained unclear.
Objectives:
We aimed to synthesize available evidence and clarify the relation between alcohol intake and risk of MCI as well as PDM.
Methods:
We searched electronic databases consisting of PubMed, EMBASE, Cochrane Library, and China Biology Medicine disc (CBM)) from inception to October 1, 2019. Only prospective studies that reported at least three level of alcohol exposure were included. Categorical meta-analysis was used for quantitative synthesis of the relation between light, moderate and heavy alcohol intake with risk of MCI and PDM. Restricted cubic spline and fixed-effects dose-response models were used for dose-response analysis.
Results:
Six prospective cohort studies including 4,244 individuals were finally included. We observed an unstable linear relation between alcohol intake (drinks/week) and risk of MCI (P-linear=0.0396). It suggested that a one-drink increment per week of alcohol intake was associated with an increased risk of 3.8% for MCI (RR, 1.038; 95%CI: 1.002-1.075). Heavy alcohol intake (>14 drinks/week) was associated with high risk of PDM (RR=1.76; 95%CI: 1.10-2.82). And we found a nonlinear relation between alcohol intake and risk of PDM. Drinking more than 16 drinks/week (P-nonlinear=0.0038, HR=1.42; 95%CI: 1.00-2.02), or 27.5 grams/day (P-nonlinear=0.0047, HR=1.46; 95%CI: 1.00-2.11) would increase the risk of PDM.
Conclusions:
There was a nonlinear dose-response relation between alcohol intake and risk of PDM. Excessive alcohol intake (>16 drinks/week, or 27.5 grams/day) was associated with higher risk of PDM. And there was an unstable linear dose-response relation between alcohol intake and risk of MCI.
Patient or healthcare consumer involvement:
There was no patient or healthcare consumer in this project.