Article type
Year
Abstract
Background:
Recently, there is a shift from consensus guideline to evidence informed guideline in India. The need for reliability evaluation of the evidence bodies is increasing. But there is no clear methodology regarding the reliability of evidence on infectious disease prevalence in the country unlike the evidences for intervention and diagnosis. This study been conducted to address the questions raised on the prevalence of invasive pneumococcal disease among Indian children by developing a tool to assess the reliability of Indian evidence.
Objectives:
To access the reliability of the evidence about magnitude of invasive pneumococcal disease among Indian children
Methods:
A three-step approach was used to develop a tool to assess the reliability of the evidence for invasive pneumococcal disease in India. A qualitative study comprised 3 focus group discussions, including expert clinicians, researchers having experience of conducting systematic reviews on infectious diseases in order to identify relevant constructs to be included in the modified Delphi survey (N=2). Delphi conducted to develop a frame work, build consensus and finally apply the same to the exiting systematic reviews of prevalence of IPD in Indian children. The experts for Delphi were chosen using the convenient sampling methods and were advised to follow the principles of GRADE approach for interventions
Results:
After three rounds of focused group discussions with 6 subject experts and 2 rounds of modified delphi method with relevant experts a reliability assessment tool was developed that had a 10-point scoring system for evidence on magnitude of disease form cross-sectional descriptive studies. The experts followed the GRADE principles and the resultant assessment tool had 5 domains-survey design, RoB assessment, indirectness of the evidence variations and adjustments for confounding. with highest score of 10.
The evidence body for magnitude of invasive pneumococcal disease in Indian children was subject to the assessment tool and scored low.
Conclusions:
The framework developed for descriptive studies on IPD showed that the evidence on Indian children in unreliable and needs more studies with rigorous methodology
Recently, there is a shift from consensus guideline to evidence informed guideline in India. The need for reliability evaluation of the evidence bodies is increasing. But there is no clear methodology regarding the reliability of evidence on infectious disease prevalence in the country unlike the evidences for intervention and diagnosis. This study been conducted to address the questions raised on the prevalence of invasive pneumococcal disease among Indian children by developing a tool to assess the reliability of Indian evidence.
Objectives:
To access the reliability of the evidence about magnitude of invasive pneumococcal disease among Indian children
Methods:
A three-step approach was used to develop a tool to assess the reliability of the evidence for invasive pneumococcal disease in India. A qualitative study comprised 3 focus group discussions, including expert clinicians, researchers having experience of conducting systematic reviews on infectious diseases in order to identify relevant constructs to be included in the modified Delphi survey (N=2). Delphi conducted to develop a frame work, build consensus and finally apply the same to the exiting systematic reviews of prevalence of IPD in Indian children. The experts for Delphi were chosen using the convenient sampling methods and were advised to follow the principles of GRADE approach for interventions
Results:
After three rounds of focused group discussions with 6 subject experts and 2 rounds of modified delphi method with relevant experts a reliability assessment tool was developed that had a 10-point scoring system for evidence on magnitude of disease form cross-sectional descriptive studies. The experts followed the GRADE principles and the resultant assessment tool had 5 domains-survey design, RoB assessment, indirectness of the evidence variations and adjustments for confounding. with highest score of 10.
The evidence body for magnitude of invasive pneumococcal disease in Indian children was subject to the assessment tool and scored low.
Conclusions:
The framework developed for descriptive studies on IPD showed that the evidence on Indian children in unreliable and needs more studies with rigorous methodology