Article type
Year
Abstract
Background:Viral hepatitis is a large global health burden. With hepatitis B virus (HBV) and hepatitis C virus (HCV) accountable for an estimated 1.3 million deaths in 2016 and approximately 325 million persons living with the virus, the World Health Organization defined elimination goals of 90% reduction in incidence and a 65% reduction in hepatitis B- and C-related mortality by 2030.
Objectives:Identify, compile and disseminate evidence on global research priorities to facilitate worldwide hepatitis elimination efforts.
Methods:The Coalition for Global Hepatitis Elimination has adopted a process for identifying and compiling evidence on viral hepatitis. A Technical Advisory Board prioritize global research topics. Evidence identified from peer-reviewed and grey literature sources on each priority topic undergoes rigorous systematic review methods, including screening and data extraction. Summary “cards” of eligible studies across each topic area are tagged based on target population, key intervention, evidence type, and virus targets and disseminated on a central evidence base website.
Results:Currently, the Coalition for Global Hepatitis Elimination evidence base presents critically appraised systematic reviews and guidelines for the topic of timely HBV birth dose vaccination; regional, national, state and city plans for HBV and HCV control and elimination featuring goals, policies, interventions and targets; and care cascade outcomes associated with HCV testing strategies.
Conclusions:Systematic review methods introduce rigor and transparency to the identification of evidence to support global hepatitis elimination efforts. Coupled with an online platform, the evidence summaries and search engine allow for knowledge translation and dissemination efforts to organizations and partners.
Patient or healthcare consumer involvement:No
Objectives:Identify, compile and disseminate evidence on global research priorities to facilitate worldwide hepatitis elimination efforts.
Methods:The Coalition for Global Hepatitis Elimination has adopted a process for identifying and compiling evidence on viral hepatitis. A Technical Advisory Board prioritize global research topics. Evidence identified from peer-reviewed and grey literature sources on each priority topic undergoes rigorous systematic review methods, including screening and data extraction. Summary “cards” of eligible studies across each topic area are tagged based on target population, key intervention, evidence type, and virus targets and disseminated on a central evidence base website.
Results:Currently, the Coalition for Global Hepatitis Elimination evidence base presents critically appraised systematic reviews and guidelines for the topic of timely HBV birth dose vaccination; regional, national, state and city plans for HBV and HCV control and elimination featuring goals, policies, interventions and targets; and care cascade outcomes associated with HCV testing strategies.
Conclusions:Systematic review methods introduce rigor and transparency to the identification of evidence to support global hepatitis elimination efforts. Coupled with an online platform, the evidence summaries and search engine allow for knowledge translation and dissemination efforts to organizations and partners.
Patient or healthcare consumer involvement:No