Background: Population is growing older rapidly throughout the world in recent centuries. Healthy aging has become an extremely challenging issue. Frailty, a geriatric syndrome resulted from the declines of multiple physiological systems, characterized by malnutrition, exercise intolerance, dependence, longer bed rest, lower gaits peed, weakness, weight loss, anorexia, hip fracture, risk of falling, delirium, dementia, and keep indoors, has become one of the biggest challenges in facilitating healthy aging. Several organizations have developed clinical practice guidelines (CPGs) to guide patients and health-care staff to screen and manage frailty in older adults. However, these CPGs recommendations may be inconsistent, and their quality is still unknown.

Objectives: To systematically review the consistency of globally available clinical practice guidelines recommendations on the screen and management of frailty, and to assessed their methodological and reporting quality.

Methods: We searched PubMed, EMBASE, Web of science, CNKI, WanFang data, Guidelines International Network (GIN), National Institute for Health and Clinical Excellence (NICE), National Guideline Clearinghouse (NGC), Scottish Intercollegiate Guidelines Network, British Geriatrics Society (BGS), and American Geriatrics Society (AGS) to identified related CPGs. And we used Rayyan online literature management software to manage the literature search records. Two reviewers independently screened the title and abstract of all retrieved bibliographic records according to our eligibility criteria. Any conflict will be resolved by a third reviewer. The following information was extracted independently: basic characteristic (title, population, development organization or individual, year of publication, country, and funding source), source of evidence (whether it was systematically retrieved evidence, databases that it was searched, whether report the detail search strategy, beginning and end years of search, method of evidence grading), detail recommendation information (grading systems, recommendation for frailty screen, recommendation for frailty assessment, recommendation for frailty management, the basis of recommendations forming, strength of recommendation). Four researchers independently assessed their methodological and reporting quality using the AGREE II instrument and RIGHT checklist.

Results: This study is ongoing and results will be presented at Colloquium as available.

Conclusions: This study is ongoing and results will be presented at Colloquium as available.

Patient or healthcare consumer involvement: Not Applicable