Article type
Year
Abstract
Background:
The development of Clinical practice guidelines (CPGs) must be fair and transparent. Conflicts of interests (COIs) is one of the most important factors affecting the independence and reliability of guidelines. The existence of conflicts of interest may lead to the exaggeration of ineffective interventions and the concealment of effective interventions, which is an important source of potential bias in the development of guidelines. As the criteria of developing guidelines, so many guidance documents have referred to how to declare and manage the Conflicts of interests. But there has no detailed description of such as whether the definition or sort of COIs are difference and whether the method of interest management is same. However, this point is directly related to the quality, credibility and authority of the guidelines developed by referring to different guidance document makers.
Objectives:
To assess how guidance documents for developing clinical practice guidelines (CPGs) address the conflict of interest during the development of clinical guidelines.
Methods:
We collected the guidance documents for developing clinical practice guidelines by searching PubMed and Google search engine (Alphabet). The reference lists of all eligible documents and relevant literatures were also perused for additional materials not captured by the aforementioned searches. We included documents that provided guidance on the entire development process of practice guidelines and mentioned COIs. Documents that were written by individuals, were outdated versions that had been subsequently updated, or were focused on specific aspects of guideline development (such as updating; systematic reviews, or the GRADE process) were excluded. Two researchers independently screened the records and extracted data. We extracted the title of guidance documents, publication date, development organization etc. as basic information. For the information on COIs, the primary framework was based on the form of WHO Handbook for Guideline Development (2nd edition), and the information outside the primary framework were supplemented in an iterative way. The information related to COIs in the current guidance documents were finally comprehensively summarized and graded according to the frequency of the report.
Results:
A total of 89 guidance documents were retrieved, 66 were reported COIs. The detailed information of COIs will be presented at the meeting.
Conclusions:
The results will be presented at the meeting
Patient or healthcare consumer involvement:
None
The development of Clinical practice guidelines (CPGs) must be fair and transparent. Conflicts of interests (COIs) is one of the most important factors affecting the independence and reliability of guidelines. The existence of conflicts of interest may lead to the exaggeration of ineffective interventions and the concealment of effective interventions, which is an important source of potential bias in the development of guidelines. As the criteria of developing guidelines, so many guidance documents have referred to how to declare and manage the Conflicts of interests. But there has no detailed description of such as whether the definition or sort of COIs are difference and whether the method of interest management is same. However, this point is directly related to the quality, credibility and authority of the guidelines developed by referring to different guidance document makers.
Objectives:
To assess how guidance documents for developing clinical practice guidelines (CPGs) address the conflict of interest during the development of clinical guidelines.
Methods:
We collected the guidance documents for developing clinical practice guidelines by searching PubMed and Google search engine (Alphabet). The reference lists of all eligible documents and relevant literatures were also perused for additional materials not captured by the aforementioned searches. We included documents that provided guidance on the entire development process of practice guidelines and mentioned COIs. Documents that were written by individuals, were outdated versions that had been subsequently updated, or were focused on specific aspects of guideline development (such as updating; systematic reviews, or the GRADE process) were excluded. Two researchers independently screened the records and extracted data. We extracted the title of guidance documents, publication date, development organization etc. as basic information. For the information on COIs, the primary framework was based on the form of WHO Handbook for Guideline Development (2nd edition), and the information outside the primary framework were supplemented in an iterative way. The information related to COIs in the current guidance documents were finally comprehensively summarized and graded according to the frequency of the report.
Results:
A total of 89 guidance documents were retrieved, 66 were reported COIs. The detailed information of COIs will be presented at the meeting.
Conclusions:
The results will be presented at the meeting
Patient or healthcare consumer involvement:
None