Article type
Year
Abstract
Background: High-quality randomized clinical trials (RCTs) occupy an extremely important position on the evidence pyramid, either as standalone studies or as part of clinical practice guidelines. However, retracted RCTs may affect the development of clinical practice guidelines and hence on recommendations to stakeholders. Understanding the reasons for the withdrawal of RCTs and their impact on clinical practice guidelines is essential for authors to circumvent common problems, as well as for the guideline developers and other evidence users to judge the reliability of RCT results.
Objectives: To investigate the reasons for RCT retraction and the impact of retracted RCTs on clinical practice guidelines.
Methods: Electronic databases (including PubMed and Embase) and Retraction Watch were retrieved from their inception until March, 27 2020. We searched "Retracted, Retraction, Withdrawal, Withdrawn, Randomized Controlled Trial, placebo”words in the form of keywords combined with free words. Two researchers independently screened the records and extracted data, non-medical RCTs were excluded, disagreements were resolved through discussion or consulting a third researcher. Data processing was performed by Stata statistical software 14 to present descriptive results.
Results: A total of 3471 studies were retrieved and eventually we included 445 retracted RCTs. The reasons of reaction and their impacted on clinical practice guidelines will be presented at the meeting.
Conclusions: The results will be presented at the meeting.
Patient or healthcare consumer involvement: None
Objectives: To investigate the reasons for RCT retraction and the impact of retracted RCTs on clinical practice guidelines.
Methods: Electronic databases (including PubMed and Embase) and Retraction Watch were retrieved from their inception until March, 27 2020. We searched "Retracted, Retraction, Withdrawal, Withdrawn, Randomized Controlled Trial, placebo”words in the form of keywords combined with free words. Two researchers independently screened the records and extracted data, non-medical RCTs were excluded, disagreements were resolved through discussion or consulting a third researcher. Data processing was performed by Stata statistical software 14 to present descriptive results.
Results: A total of 3471 studies were retrieved and eventually we included 445 retracted RCTs. The reasons of reaction and their impacted on clinical practice guidelines will be presented at the meeting.
Conclusions: The results will be presented at the meeting.
Patient or healthcare consumer involvement: None