Article type
Year
Abstract
Background:
Head and neck cancer (HNC) covers a heterogeneous group of cancers, which includes paranasal and sinonasal cancer and cancer of the salivary gland, lip, oral cavity, pharynx and larynx. Treatment options for HNC consist of radiotherapy, surgery, chemotherapy or a combination of these modalities. There is a growing body of evidence suggesting that more aggressive treatment regimes, such as altered fractionation schedules for radiotherapy or (concomitant) chemoradiation improve tumor control and survival.
Objectives:
To assess the overall survival (OL) rates, local control (LC) rates and progression-free survival (PFS) of radiation therapy for head and neck cancers and identify the difference in LC and toxicity between adjuvant, salvage, and primary therapy using radiation.
Methods:
We conducted a systematic literature review using PubMed Web of science and Embase databases to assess information available regarding the overall survival (OS) rates, LC rates, progression-free survival (PFS)and Recurrence for carbon-ion and proton radiation therapy for head and neck cancers. Two reviewers independently extracted the data. The Case series evaluation tool was used to assess the quality of included studies. The Stata 12.0 software were used to performed Meta-analysis.
Results:
In this systematic review, a total of ten articles were included, involving 701 participants. The quality of the included studies ranged from moderate to high. The results of the meta-analysis showed that 5-year overall survival was significantly higher after carbon-ion therapy compared to conventional protons therapy (52% versus 44%, P-value 0.007). Also, 5-year local control after carbon-ion therapy was significantly higher for head and neck cancer compared to protons therapy (92% versus 74%, P-value 0.045). The meta-analysis showed two and five-year progression-free survival after carbon-ion therapy is 42% and 45%. In addition, significant reductions were observed in recurrence rates(28%,I2=89%).
Conclusions:
Compared with the proton therapy, carbon ion radiation therapy may prolong the overall survival of patients with head and neck cancer at 2 and 5 years. In addition, carbon ion radiotherapy may have significant effects on local control rates, progression-free survival rates, adverse reactions, and reduction of recurrence rates in patients with head and neck cancer. however, since the overall quantity and quality of data regarding carbon-ion and proton therapy is poor and high heterogeneity across trials., need to be interpreted with caution. Well-designed and rigorous studies will be required in the future.
Patient or healthcare consumer involvement: Not application
Head and neck cancer (HNC) covers a heterogeneous group of cancers, which includes paranasal and sinonasal cancer and cancer of the salivary gland, lip, oral cavity, pharynx and larynx. Treatment options for HNC consist of radiotherapy, surgery, chemotherapy or a combination of these modalities. There is a growing body of evidence suggesting that more aggressive treatment regimes, such as altered fractionation schedules for radiotherapy or (concomitant) chemoradiation improve tumor control and survival.
Objectives:
To assess the overall survival (OL) rates, local control (LC) rates and progression-free survival (PFS) of radiation therapy for head and neck cancers and identify the difference in LC and toxicity between adjuvant, salvage, and primary therapy using radiation.
Methods:
We conducted a systematic literature review using PubMed Web of science and Embase databases to assess information available regarding the overall survival (OS) rates, LC rates, progression-free survival (PFS)and Recurrence for carbon-ion and proton radiation therapy for head and neck cancers. Two reviewers independently extracted the data. The Case series evaluation tool was used to assess the quality of included studies. The Stata 12.0 software were used to performed Meta-analysis.
Results:
In this systematic review, a total of ten articles were included, involving 701 participants. The quality of the included studies ranged from moderate to high. The results of the meta-analysis showed that 5-year overall survival was significantly higher after carbon-ion therapy compared to conventional protons therapy (52% versus 44%, P-value 0.007). Also, 5-year local control after carbon-ion therapy was significantly higher for head and neck cancer compared to protons therapy (92% versus 74%, P-value 0.045). The meta-analysis showed two and five-year progression-free survival after carbon-ion therapy is 42% and 45%. In addition, significant reductions were observed in recurrence rates(28%,I2=89%).
Conclusions:
Compared with the proton therapy, carbon ion radiation therapy may prolong the overall survival of patients with head and neck cancer at 2 and 5 years. In addition, carbon ion radiotherapy may have significant effects on local control rates, progression-free survival rates, adverse reactions, and reduction of recurrence rates in patients with head and neck cancer. however, since the overall quantity and quality of data regarding carbon-ion and proton therapy is poor and high heterogeneity across trials., need to be interpreted with caution. Well-designed and rigorous studies will be required in the future.
Patient or healthcare consumer involvement: Not application