Article type
Abstract
Background: Adverse childhood experiences (ACEs) are traumatic and distressing events that occur under the age of 18 to a child or a child's family and social environment. Objective: The primary purpose of this study is to describe characteristics of interventions rigorously evaluated in randomized controlled trials (RCT) and assess their effectiveness in mitigating the negative outcomes of ACEs by ACE category. Methods Contribution: The project utilizes a comprehensive and transparent synthesis of existing evidence utilizing the ROBIS and GRAMMS tools to help minimize bias and error.
Progress update: The data collection and analysis phases are underway. Anticipated Outcomes: Initial findings indicate that interventions tested in RCTs have included counseling, psychodynamic, and cognitive behavior therapy, with outcomes evaluated that include mental health, physical health, and behavior-focused outcomes. Still, comprehensive conclusions cannot be drawn yet. However, the challenges encountered include effectively synthesizing different outcomes, including patient-reported outcomes, biomarkers, or other clinical endpoints of intervention effectiveness. We are resolving this by modifying the review method that allows us to characterize rigorously evaluated interventions.
Relevance to patients: The significance of this research lies in the contribution of the methods and the potential contributions of the description of study designs, measures, specific outcomes, and theoretical foundations for future intervention development. Conclusion: Upon completion, the findings will provide valuable insights into the characteristics and outcomes of effective interventions focused on mitigating the impact of ACEs by the ACE category. Future work will focus on developing recommendations to replicate, disseminate, and inform on strategies that effectively mitigate the impact of ACEs by ACE category and inform the design of future interventions based on the lessons learned and limitations from the studies reviewed.
Progress update: The data collection and analysis phases are underway. Anticipated Outcomes: Initial findings indicate that interventions tested in RCTs have included counseling, psychodynamic, and cognitive behavior therapy, with outcomes evaluated that include mental health, physical health, and behavior-focused outcomes. Still, comprehensive conclusions cannot be drawn yet. However, the challenges encountered include effectively synthesizing different outcomes, including patient-reported outcomes, biomarkers, or other clinical endpoints of intervention effectiveness. We are resolving this by modifying the review method that allows us to characterize rigorously evaluated interventions.
Relevance to patients: The significance of this research lies in the contribution of the methods and the potential contributions of the description of study designs, measures, specific outcomes, and theoretical foundations for future intervention development. Conclusion: Upon completion, the findings will provide valuable insights into the characteristics and outcomes of effective interventions focused on mitigating the impact of ACEs by the ACE category. Future work will focus on developing recommendations to replicate, disseminate, and inform on strategies that effectively mitigate the impact of ACEs by ACE category and inform the design of future interventions based on the lessons learned and limitations from the studies reviewed.