Article type
Abstract
"Abstract
Background: Heart block, referred to as atrioventricular (AV) block, is a condition where the electrical signals coming from the heart are disrupted, resulting in abnormal heartbeats. Its intensity can vary in several circumstances, including congenital defects, drugs, injuries, and cardiac issues. Treatment options include heart performance-improving devices called pacemakers or monitoring. These devices, which aid in symptom relief and heart function improvement, include implantable dual and single-chamber pacemakers. This study evaluates their cost-effectiveness for heart block patients.
Objective: To assess the cost-effectiveness of an artificial cardiac pacemaker that is used in patients with complete heart block.
Methods: The methodology included a systematic examination of studies comparing the cost-effectiveness of single and dual-chambered pacemakers for treating heart block in patients between the ages of 51 and 70. Over the course of a lifetime, metrics like Net Monetary Benefit, Incremental Cost-Effectiveness Ratio (ICER), and Quality-Adjusted Life Years (QALYs) were assessed. For the analysis, a comprehensive bottom-up costing technique combined with a patient-focused Markov model was applied. Sensitivity analyses were carried out to guarantee the study's robustness.
Results: Among 24649 participants, 5031 who were treated without PPM had an increased risk of mortality compared to 895 patients who were treated with PPM. Dual-chamber pacemakers were found to be more cost-effective than single-chamber pacemakers, with an incremental cost-effectiveness ratio (ICER) of ₹60,871.59. The Net Monetary Benefit recommends the use of pacemakers with two chambers. Dual-chamber pacemakers are a cost-effective and potentially long-term cost-saving option for treating patients' heart blocks, as demonstrated by sensitivity analyses and Monte Carlo simulations.
Conclusions: The meta-analysis shows a decreased risk of death with pacemaker implantation. Dual chamber pacemakers are a financially sensible option for patients with heart block, according to the economic evaluation, offering improved long-term results and possible cost savings. "
Background: Heart block, referred to as atrioventricular (AV) block, is a condition where the electrical signals coming from the heart are disrupted, resulting in abnormal heartbeats. Its intensity can vary in several circumstances, including congenital defects, drugs, injuries, and cardiac issues. Treatment options include heart performance-improving devices called pacemakers or monitoring. These devices, which aid in symptom relief and heart function improvement, include implantable dual and single-chamber pacemakers. This study evaluates their cost-effectiveness for heart block patients.
Objective: To assess the cost-effectiveness of an artificial cardiac pacemaker that is used in patients with complete heart block.
Methods: The methodology included a systematic examination of studies comparing the cost-effectiveness of single and dual-chambered pacemakers for treating heart block in patients between the ages of 51 and 70. Over the course of a lifetime, metrics like Net Monetary Benefit, Incremental Cost-Effectiveness Ratio (ICER), and Quality-Adjusted Life Years (QALYs) were assessed. For the analysis, a comprehensive bottom-up costing technique combined with a patient-focused Markov model was applied. Sensitivity analyses were carried out to guarantee the study's robustness.
Results: Among 24649 participants, 5031 who were treated without PPM had an increased risk of mortality compared to 895 patients who were treated with PPM. Dual-chamber pacemakers were found to be more cost-effective than single-chamber pacemakers, with an incremental cost-effectiveness ratio (ICER) of ₹60,871.59. The Net Monetary Benefit recommends the use of pacemakers with two chambers. Dual-chamber pacemakers are a cost-effective and potentially long-term cost-saving option for treating patients' heart blocks, as demonstrated by sensitivity analyses and Monte Carlo simulations.
Conclusions: The meta-analysis shows a decreased risk of death with pacemaker implantation. Dual chamber pacemakers are a financially sensible option for patients with heart block, according to the economic evaluation, offering improved long-term results and possible cost savings. "