Descriptive Evaluation of Pediatric Comorbidity Cohort Studies:A Scoping review

Article type
Authors
Wang X1, Chen Y
1 Research Unit of Evidence-Based Evaluation and Guidelines, Chinese Academy of Medical Sciences (2021RU017), School of Basic Medical Sciences, Lanzhou University; Key Laboratory of Evidence Based Medicine of Gansu Province; WHO Collaborating Centre for Guideline Implementation and Knowledge Translation
Abstract
"Background: Comorbidity is defined as the disease that there is an interaction between the primary disease and one or more diseases occurring simultaneously or successively, but there is no complete causal relationship. Many of the conditions are also comorbid with each other in children.However,the extent of research of comorbidities in children and adloescents has not been examined or well characterised previously.

Objectives: The aim of this scoping review is to describe and summarise current literature evaluating comorbidities in children and adloescents.

Methods: The review will be performed using the framework formulated by Arksey and O’Malley.We searched PubMed, Embase and Web of science for papers written in English published from January 1,2019 to December 31,2023. Two authors screened results independently.All of pediatric cohort studies on any disease focusing on comorbidities were searched.We will extract and collect information from the identified literature, including author, year, setting, country, the diseases and multimorbidity combinations, research design, research content, sample size, and outcome indicators.The quality of the included cohort literature will be evaluated by Newcastle-Ottawa Scale (NOS).

Results: This scoping review will provide structured and detailed information on the development of important comorbidities in children and adloescents.By exploring the current types and therapeutic methods of comorbidities in children and adloescents,we can identify areas which may have untapped potential.We will also show whether different therapeutic methods have been used in the same aspect of comorbidities in children and adloescents.

Conclusions: This study will show the results of the current situation and existing problems in pediatric comorbidity cohort studies in recent years. It will identify any gaps in this field and provide suggestions for future research."