Article type
Abstract
Background: Uyghur medicine has accumulated significant clinical experience in treating psoriasis, developing various distinctive therapies and effective medications, and has generated considerable evidence of effectiveness. However, the clinical research outcomes lack standardization and recognition. Although there is a COS (Core Outcome Set) recommended for all psoriasis clinical trials regardless of intervention, there is uncertainty regarding whether Psoriasis patients treated by Uyghur medicine and Uyghur dermatologists hold different opinions.
Objectives: Seeking the opinions of psoriasis patients treated by Uyghur medicine and Uyghur dermatologists and developing an add-on module to the existing COS.
Methods: Literature review supplemented with a semi-open questionnaire survey with patients and Uyghur dermatologists, generating an initial long list of outcomes. Two rounds of a Delphi survey were conducted based on the list, obtaining Likert scores from various stakeholders on the importance of each outcome. The final inclusion of outcomes in the COS was determined through a consensus meeting.
Results: Of 11 psoriasis patients (males: 8[72.73%]) and 23 Uyghur dermatologists (males: 13[56.52%]) participated in the questionnaire survey. In round 1 of the Delphi survey, most participants (28 [80%]) were dermatologists. After the second round of the Delphi survey，26 outcomes were candidates for the consensus meeting. The following 14 outcomes reached a consensus and were included in the COS: skin manifestations, psoriasis symptoms, investigator global assessment, patient global assessment, health-related quality of life, treatment satisfaction, recurrence rate, adverse events, drug adverse reactions, blood routine, urine routine, liver and kidney function, Uyghur Medicine symptom assessment, and fluid changes.
Conclusions: This study incorporates local perspectives into the international consensus of COS, making it more conducive to its specific applications. Recommend all clinical research of Uyghur Medicine for Psoriasis report the outcomes of the COS at least.
Objectives: Seeking the opinions of psoriasis patients treated by Uyghur medicine and Uyghur dermatologists and developing an add-on module to the existing COS.
Methods: Literature review supplemented with a semi-open questionnaire survey with patients and Uyghur dermatologists, generating an initial long list of outcomes. Two rounds of a Delphi survey were conducted based on the list, obtaining Likert scores from various stakeholders on the importance of each outcome. The final inclusion of outcomes in the COS was determined through a consensus meeting.
Results: Of 11 psoriasis patients (males: 8[72.73%]) and 23 Uyghur dermatologists (males: 13[56.52%]) participated in the questionnaire survey. In round 1 of the Delphi survey, most participants (28 [80%]) were dermatologists. After the second round of the Delphi survey，26 outcomes were candidates for the consensus meeting. The following 14 outcomes reached a consensus and were included in the COS: skin manifestations, psoriasis symptoms, investigator global assessment, patient global assessment, health-related quality of life, treatment satisfaction, recurrence rate, adverse events, drug adverse reactions, blood routine, urine routine, liver and kidney function, Uyghur Medicine symptom assessment, and fluid changes.
Conclusions: This study incorporates local perspectives into the international consensus of COS, making it more conducive to its specific applications. Recommend all clinical research of Uyghur Medicine for Psoriasis report the outcomes of the COS at least.