Article type
Abstract
Background: Chronic obstructive pulmonary disease (COPD) is a common chronic airway disease. COPD is one of the top three global causes of death and ranking among the top five in the World's disease burden, over 600 million COPD patients worldwide bear a significant burden.
Objective: This systematic review and meta-analysis aim to demonstrate the Disease Burden of Chronic Obstructive Pulmonary Disease, to provide a basis for formulating reasonable prevention and control measures and allocating health resources.
Methods: We conducted systematic searches for RCTs on CNKI, VIP, WanFang Data, MEDLINE/PubMed, Web of Science, and Cochrane databases from inception until October 2023. Titles and abstracts were reviewed by two independent researchers against pre-defined inclusion and exclusion criteria. The risk of bias in the included randomized controlled trials was evaluated using the revised Cochrane tool. The meta-analysis was performed using Stata 16SE software.
Results: A total of 77 articles were included, 73 primary publications were included in this review, of which 42 (54.5%) were published in SCIE journals, and 38 (49.4%) originated from the China. The most frequently searched databases for included studies were CNKI (54.5%, n=35) and Cochrane (37.7%, n=29). 51 RCTs reported direct economic costs, 25 RCTs reported quality adjusted life years (QALYs), and 9 RCTs reported quality of life. 12 RCTs were related to mechanical ventilation (15.6%, n=12), while interventions for 10 RCTs were related to community or self-health management (13.0%, n=10). The certainty of evidence was very low to moderate for these studies.
Conclusions: Our system review and network meta-analysis suggest that mechanical ventilation, community or self-health management, and tiotropium bromide may reduce direct economic costs for patients and lower disease burden.
Objective: This systematic review and meta-analysis aim to demonstrate the Disease Burden of Chronic Obstructive Pulmonary Disease, to provide a basis for formulating reasonable prevention and control measures and allocating health resources.
Methods: We conducted systematic searches for RCTs on CNKI, VIP, WanFang Data, MEDLINE/PubMed, Web of Science, and Cochrane databases from inception until October 2023. Titles and abstracts were reviewed by two independent researchers against pre-defined inclusion and exclusion criteria. The risk of bias in the included randomized controlled trials was evaluated using the revised Cochrane tool. The meta-analysis was performed using Stata 16SE software.
Results: A total of 77 articles were included, 73 primary publications were included in this review, of which 42 (54.5%) were published in SCIE journals, and 38 (49.4%) originated from the China. The most frequently searched databases for included studies were CNKI (54.5%, n=35) and Cochrane (37.7%, n=29). 51 RCTs reported direct economic costs, 25 RCTs reported quality adjusted life years (QALYs), and 9 RCTs reported quality of life. 12 RCTs were related to mechanical ventilation (15.6%, n=12), while interventions for 10 RCTs were related to community or self-health management (13.0%, n=10). The certainty of evidence was very low to moderate for these studies.
Conclusions: Our system review and network meta-analysis suggest that mechanical ventilation, community or self-health management, and tiotropium bromide may reduce direct economic costs for patients and lower disease burden.