Article type
Abstract
Background:The incidence of obesity and overweight is increasing worldwide. Lifestyle modification and pharmacological therapy are recommended for women with overweight or obese problem who are experiencing infertility. However, there is no evidence specifying the short-term and long-term effectiveness of either treatment, thus hindering clinical recommendations at different stages.
Objectives: This systematic review and meta-analysis aimed to evaluate the short-term and long-term efficacy of both treatments on changes in weight, body mass index (BMI), reproductive hormone levels and fertility outcomes among women with overweight or obese problem who are experiencing infertility.
Methods: An electronic search of the MEDLINE, EMBASE, PsycINFO, Web of Science, CINAHL and the Cochrane Library databases for randomized clinical trials (RCTs) published until October 2022 was performed.
Results: A total of 50 studies were included. A beneficial effect on changes in weight, BMI, reproductive hormone levels, and the pregnancy rate in the short term (within 6 months) was found for both lifestyle modification and pharmacological therapy. For long-term (≥12 months) efficacy, neither lifestyle modification nor pharmacological therapy resulted in an improvement in the pregnancy rate and the outcomes of changes in weight, BMI, and reproductive hormone levels and the pregnancy complication rate for both treatments were scarcely reported.
Conclusions: Therefore, further comprehensive assessment of whether keeping nonsurgical weight loss intervention is needed if pregnancy is not conceived within six months assessment.
Objectives: This systematic review and meta-analysis aimed to evaluate the short-term and long-term efficacy of both treatments on changes in weight, body mass index (BMI), reproductive hormone levels and fertility outcomes among women with overweight or obese problem who are experiencing infertility.
Methods: An electronic search of the MEDLINE, EMBASE, PsycINFO, Web of Science, CINAHL and the Cochrane Library databases for randomized clinical trials (RCTs) published until October 2022 was performed.
Results: A total of 50 studies were included. A beneficial effect on changes in weight, BMI, reproductive hormone levels, and the pregnancy rate in the short term (within 6 months) was found for both lifestyle modification and pharmacological therapy. For long-term (≥12 months) efficacy, neither lifestyle modification nor pharmacological therapy resulted in an improvement in the pregnancy rate and the outcomes of changes in weight, BMI, and reproductive hormone levels and the pregnancy complication rate for both treatments were scarcely reported.
Conclusions: Therefore, further comprehensive assessment of whether keeping nonsurgical weight loss intervention is needed if pregnancy is not conceived within six months assessment.