Background: Clinical practice guidelines (CPGs) are important and recognized resources aimed at supporting decision-making by presenting evidence-based recommendations. Involving diverse stakeholders is crucial for ensuring the quality and relevance of CPGs. However, stimulating participation from specialist healthcare professionals and patient representatives remains a challenge.

Objective: To develop a strategy to improve and encourage active involvement by the specialist and patient in the development of CPGs

Methodology: Specific instructional materials were developed in collaboration with Brazilian Ministry of Health technicians. These materials aim to elucidate the roles of both specialists and patients in the guideline development process and underscore the significance of their contributions.

Results: The instructional materials were customized for specific audiences. For specialists, detailed guidance explained their role in ministry meetings, encompassing both preparatory stages and updates to CPGs. Patient-focused materials were presented in accessible language, initially outlining the purpose of CPGs before presenting ways patients can actively participate. This included sharing personal experiences with the disease and its impact on patients' daily life and family dynamics and exploring management options. Additionally, both groups were provided with instructions for scoping and prescoping meetings, along with guidance on how to declare conflicts of interest to ensure transparency and integrity in the CPG development process.

Conclusion: Recognizing the role of instructional materials, we expect that these resources will serve as an important stimulus to increase specialist and patient engagement in CPG formulation. Ongoing evaluation through surveys will further clarify the effectiveness and utility of these materials, guiding future research and strategies for maximizing stakeholder involvement.