Article type
Abstract
Background: Malaria, a parasitic infection transmitted by bite of the female Anopheline mosquito, congenitally, or through exposure to infected blood products. Pregnant women at risk and it usually have more severe symptoms and negative consequences to both the mother and fetus. Therefore, this study aimed pooling evidences on malaria during pregnancy from systematic review and meta-analysis.
Methods: This Umbrella review of systematic review and meta-analysis was searched from electronic data bases like PubMed, Embase, Scopus, Web of Sciences, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, PDQ evidence, Google Scholar and Universities repositories were manually searched. Systematic review and/or meta-analysis studies on prevalence of Malaria among pregnant mothers globally was reviewed. The study methodological quality was assessed using the Assessment of Multiple Systematic Reviews (AMSTAR) tool. Authors have also assessed heterogeneity of evidences using I2 checked and sub-group analysis based on the country of systematic review and meta-analysis. The pooled estimates of the prevalence of malaria among pregnant mother was summarized with random-effects meta-analysis models. The protocol was registered on Prospero and obtained CRD42024504605.
Results: A total 309 eligible papers from systematic review and meta-analysis involving 292360 pregnant mothers were enrolled constituting 74908 mothers with malaria during pregnancy. It reported that the pooled prevalence of malaria among pregnant mothers was 27.36% at 95% CI (13.97, 40.76). Subgroup analysis reveals that there is significant prevalence of malaria among pregnant mothers’ countries like Sudan 25.51% and Nigeria 36.35%. Even though, the funnel plot show presence of publication bias Egger’s and Begg’s test indicates there was no publication bias.
Conclusions: The study review reveals that there is considerable number of malarias among pregnant mothers. This indicates that the prevention strategy should strengthen priority setting for especial population those can be easily affected by malaria. In another way it is message that there is ongoing malaria transmission throughout the globe with especial prevalence in sub-Saharan Africa. Therefore, regional and population specific interventions have to encouraged.
Methods: This Umbrella review of systematic review and meta-analysis was searched from electronic data bases like PubMed, Embase, Scopus, Web of Sciences, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, PDQ evidence, Google Scholar and Universities repositories were manually searched. Systematic review and/or meta-analysis studies on prevalence of Malaria among pregnant mothers globally was reviewed. The study methodological quality was assessed using the Assessment of Multiple Systematic Reviews (AMSTAR) tool. Authors have also assessed heterogeneity of evidences using I2 checked and sub-group analysis based on the country of systematic review and meta-analysis. The pooled estimates of the prevalence of malaria among pregnant mother was summarized with random-effects meta-analysis models. The protocol was registered on Prospero and obtained CRD42024504605.
Results: A total 309 eligible papers from systematic review and meta-analysis involving 292360 pregnant mothers were enrolled constituting 74908 mothers with malaria during pregnancy. It reported that the pooled prevalence of malaria among pregnant mothers was 27.36% at 95% CI (13.97, 40.76). Subgroup analysis reveals that there is significant prevalence of malaria among pregnant mothers’ countries like Sudan 25.51% and Nigeria 36.35%. Even though, the funnel plot show presence of publication bias Egger’s and Begg’s test indicates there was no publication bias.
Conclusions: The study review reveals that there is considerable number of malarias among pregnant mothers. This indicates that the prevention strategy should strengthen priority setting for especial population those can be easily affected by malaria. In another way it is message that there is ongoing malaria transmission throughout the globe with especial prevalence in sub-Saharan Africa. Therefore, regional and population specific interventions have to encouraged.