Article type
Abstract
"Introduction:
Publicly funded research must be aligned with locally prioritised health topics, aiming to inform clinical practice guidelines (CPGs). In Chile, 85 health problems have been prioritised mainly based on the burden of disease (and other governance considerations), and the Chilean Ministry of Health is committed to developing CPGs for each of them. However, it is unclear whether the clinical research conducted in Chile addresses locally prioritised health topics.
Objective:
To characterise the Chilean clinical research published from 2000 onwards, and to estimate the proportion of publicly funded research addressing locally prioritised health conditions.
Methods:
We conducted a scoping review. We searched MEDLINE, Embase, PsycINFO, CINAHL, LILACS, and WoS and performed hand searches to retrieve studies conducted in Chile or by authors whose affiliations are based in Chile from 2000 onwards. We extracted bibliometric data, study design, area of study, authorship data, diseases or health conditions addressed, funding, and conflicts of interest.
Results:
After deduplication, we retrieved 56,233 references. To date, 32,000 studies have been excluded by title/abstract screening. Among 19,535 full-texts assessed for eligibility, 4,816 have been excluded for being conducted in other countries or having authors non-based in Chile, whereas 2,647 have been excluded due to other reasons (wrong publication type or no clinical topic). Preliminarily, we have identified a total of 12,072 Chilean studies, of which 7092 have been extracted. 2064 studies received public funding, among which 300 (14.53%) were randomised clinical trials, 503 (24.37%) cohort studies, 47 (2.27%) quasi-experimental studies, and 228 (11.04%) corresponded to systematic reviews. We have identified 1781 (86.28%) publicly funded studies not addressing any of the most burdensome diseases in Chile. We expect to complete the data extraction soon and to perform a detailed analysis of the alignment between clinical studies and the burden of disease, for each of the ten conditions with the highest burden of disease.
Conclusion:
Most of the Chilean clinical research receiving public funding do not address locally prioritised problems. Countries as Chile a need to strengthen the research agenda to assign public funds with cost-effectiveness criteria. This scoping review is part of a broader government-funded project (DOI:10.1136/bmjopen-2021-057555).
"
Publicly funded research must be aligned with locally prioritised health topics, aiming to inform clinical practice guidelines (CPGs). In Chile, 85 health problems have been prioritised mainly based on the burden of disease (and other governance considerations), and the Chilean Ministry of Health is committed to developing CPGs for each of them. However, it is unclear whether the clinical research conducted in Chile addresses locally prioritised health topics.
Objective:
To characterise the Chilean clinical research published from 2000 onwards, and to estimate the proportion of publicly funded research addressing locally prioritised health conditions.
Methods:
We conducted a scoping review. We searched MEDLINE, Embase, PsycINFO, CINAHL, LILACS, and WoS and performed hand searches to retrieve studies conducted in Chile or by authors whose affiliations are based in Chile from 2000 onwards. We extracted bibliometric data, study design, area of study, authorship data, diseases or health conditions addressed, funding, and conflicts of interest.
Results:
After deduplication, we retrieved 56,233 references. To date, 32,000 studies have been excluded by title/abstract screening. Among 19,535 full-texts assessed for eligibility, 4,816 have been excluded for being conducted in other countries or having authors non-based in Chile, whereas 2,647 have been excluded due to other reasons (wrong publication type or no clinical topic). Preliminarily, we have identified a total of 12,072 Chilean studies, of which 7092 have been extracted. 2064 studies received public funding, among which 300 (14.53%) were randomised clinical trials, 503 (24.37%) cohort studies, 47 (2.27%) quasi-experimental studies, and 228 (11.04%) corresponded to systematic reviews. We have identified 1781 (86.28%) publicly funded studies not addressing any of the most burdensome diseases in Chile. We expect to complete the data extraction soon and to perform a detailed analysis of the alignment between clinical studies and the burden of disease, for each of the ten conditions with the highest burden of disease.
Conclusion:
Most of the Chilean clinical research receiving public funding do not address locally prioritised problems. Countries as Chile a need to strengthen the research agenda to assign public funds with cost-effectiveness criteria. This scoping review is part of a broader government-funded project (DOI:10.1136/bmjopen-2021-057555).
"