Article type
Abstract
"Background: Newborns experience pain during routine neonatal care, including blood sampling, injection of vitamin K, or vaccination. Because newborns are unable to express their feelings effectively, the problems associated with untimely pain relief may affect their future growth and development. Non-pharmacological therapy such as breastfeeding and music therapy had a positive effect on relieving pain.
Objective: To assess and compare the efficacy of various non-pharmacological therapy for pain relief after newborn needle-related procedures using the network meta-analysis.
Methods: PubMed, Web of Science, EMBASE and Cochrane Library databases were systematically searched for eligible randomized controlled trials reports. The risk of bias of RCTs included in this study was assessed according to the Cochrane Handbook tool. Network meta-analysis was conducted to figure out the network diagram, league figures, and the final surface under the cumulative ranking curve (SUCRA) value using STATA 15.1.
Results: A total of 80 randomized controlled trials included 7898 patients and involved 11 nonpharmacological interventions. For the indicator of pain score, compared with routine care, Breast feeding/milk intervention（SMD = -1.55; 95% CI: -1.92,-1.17; SUCRA = 85.3%） had the best effect, followed by Kangaroo mother care (KMC)（SMD = -1.58; 95% CI: -2.14,-1.02; SUCRA = 84.8%）, Glusoce/Dextrose（SMD = -1.46; 95% CI: -1.88,-1.04; SUCRA = 77.9%）, Non-nutritive sucking (NNS)（SMD = -1.38; 95% CI: -1.87,-0.89; SUCRA = 71.8%）, Sucrose（SMD = -1.24; 95% CI: -1.66,-0.81; SUCRA = 60.5%）, Skin to skin care (SSC)（SMD = -1.01; 95% CI: -1.94,-0.08; SUCRA = 47.3%）, Contact（SMD = -1.03; 95% CI: -1.44,-0.61; SUCRA = 45.0%）, and Odour（SMD = -0.71; 95% CI: -1.34,-0.07; SUCRA = 28.5%）, all had pain-reducing effects. Additional results are ongoing and results will be presented at Colloquium as available.
Conclusion: Breast feeding/milk has the best effect on relieving needle-related pain in newborns, and clinicians can use this method to assist neonatal-related treatments."
Objective: To assess and compare the efficacy of various non-pharmacological therapy for pain relief after newborn needle-related procedures using the network meta-analysis.
Methods: PubMed, Web of Science, EMBASE and Cochrane Library databases were systematically searched for eligible randomized controlled trials reports. The risk of bias of RCTs included in this study was assessed according to the Cochrane Handbook tool. Network meta-analysis was conducted to figure out the network diagram, league figures, and the final surface under the cumulative ranking curve (SUCRA) value using STATA 15.1.
Results: A total of 80 randomized controlled trials included 7898 patients and involved 11 nonpharmacological interventions. For the indicator of pain score, compared with routine care, Breast feeding/milk intervention（SMD = -1.55; 95% CI: -1.92,-1.17; SUCRA = 85.3%） had the best effect, followed by Kangaroo mother care (KMC)（SMD = -1.58; 95% CI: -2.14,-1.02; SUCRA = 84.8%）, Glusoce/Dextrose（SMD = -1.46; 95% CI: -1.88,-1.04; SUCRA = 77.9%）, Non-nutritive sucking (NNS)（SMD = -1.38; 95% CI: -1.87,-0.89; SUCRA = 71.8%）, Sucrose（SMD = -1.24; 95% CI: -1.66,-0.81; SUCRA = 60.5%）, Skin to skin care (SSC)（SMD = -1.01; 95% CI: -1.94,-0.08; SUCRA = 47.3%）, Contact（SMD = -1.03; 95% CI: -1.44,-0.61; SUCRA = 45.0%）, and Odour（SMD = -0.71; 95% CI: -1.34,-0.07; SUCRA = 28.5%）, all had pain-reducing effects. Additional results are ongoing and results will be presented at Colloquium as available.
Conclusion: Breast feeding/milk has the best effect on relieving needle-related pain in newborns, and clinicians can use this method to assist neonatal-related treatments."