Summary of best evidence for airway management of mechanical ventilation in critically ill obese patients

Article type
Authors
Cao X1, Wang Y
1The First Hospital Of Jilin University, Chaoyang District, Changchun City, Jilin Province, jilin, China
Abstract
"Background Obesity is a chronic disease in which the excessive or abnormal distribution of fat tissue leads to inflammation and metabolic dysfunction, with BMI ≥30 kg/m2.In March 2023, the World Obesity Alliance pointed out that the global incidence of obesity is on the rise, and it is expected that by 2035, more than 4 billion people in the world will be overweight/obese. Obesity will lead to many health problems, including diabetes, heart disease, and stroke, becoming one of the serious public health problems. Obese patients account for 15% to 40% of all patients in the ICU. Obesity can lead to changes in respiratory anatomy and physiology, requiring complex airway management and ventilator settings during mechanical ventilation. At present, the evidence on airway management of mechanical ventilation in obese patients is scattered. Therefore, this study searched literature on mechanical ventilation airway management in patients with obesity, summarized the best evidence, and provided reference for mechanical ventilation airway management in clinical patients with severe obesity.
Objectives To retrieve,appraise and integrate the evidence on airway management of mechanical ventilation in critically ill obese patients.
Methods We searched the literatures on airway management of mechanical ventilation in critically ill obese patients across multiple databases, including BMJ best practice, UpToDate, International Guidelines International Network, Cochrane Library, PubMed, Web of Science. The study design includes clinical decision-making, clinical practice guideline, evidence summary, systematic review, expert consensus and randomized controlled trial. The literature retrieval time limit was from the establishment of the database to February 2024. The evidence was extracted and summarized according to the subject after the independent literature quality evaluation by 2 researchers.
Results 14 relevant pieces of literature were identified, including 2 guidelines, 1 consensus statement, 3 systematic reviews, 3 randomized controlled trial, and 5 clinical decision-making, which provided 17 evidences across 5 key themes,including airway assessment, preparation for tracheal intubation, mechanical ventilation parameter setting, tracheal intubation extubation and tracheostomy.
Conclusions This study summarizes the best available evidence on airway management of mechanical ventilation in critically ill obese patients. It is recommended that healthcare professionals selectively apply the best evidence based on clinical conditions."