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Displaying 1 - 20 of 160 records Index
Poster 'Sometimes similar, sometimes different': a systematic review of meta-analyses of random and nonrandomized policy intervention studies
2006 Dublin
Shepherd, Bagnall, Colquitt, Dinnes, Duffy, Sowden
Background: While the randomized controlled trial (RCT) is generally regarded as the design of choice in health care, within public policy there is considerable debate about the suitability of RCTs and non-randomized studies (NRS). As the first stage of a study to explore effect sizes from…
Poster A consumer-led project on evidence-based healthcare information for consumers
2006 Dublin
Coghlan, Brinkman, Fournier, Hart, Horgan, McKenzie, Parnell, Pierce, Wale, Chippindall
Background: This project is to inform the use of evidence-based information in healthcare consultations. It is funded by the Australian Department of Health and Ageing (Category Two funding for Cochrane entity activities in Australia).
Objectives: To develop materials promoting the use of…
Poster A hybrid effects model for bias-risk adjusting meta-analysis
2006 Dublin
Thorlund, Wetterslev, Brok
Background: Fixed-effect and random-effects models may lack consistency when heterogeneity is present. When systematic bias causes heterogeneity both models may perform poorly.
Objectives: To incorporate bias-risk adjustment in meta-analyses with heterogeneity.
Material: We searched The Cochrane…
Poster A method of prioritising review topics: map the distribution of randomized controlled trials (RCTs) in the Cochrane Review Group Trials Register
2006 Dublin
Bellorini, Dorée
Background: The prioritisation of relevant and productive systematic reviews is a central concern of The Cochrane Collaboration. It is also of increasing interest to funders. There are many ways in which Cochrane Review Groups (CRGs) can attempt to prioritise review topics. We sought to generate a…
Poster A project to help Cochrane Review Groups (CRGs) to improve the quality of Cochrane reviews on Traditional Chinese Medicine (TCM)
2006 Dublin
Zhang, Li, Li, Wu, Li, Wang
Background: Though the number of Cochrane reviews on TCM has been increasing, problems have affected the quality of reviews on TCM including inconsistency in methodology, misuse of terminology, and poor writing. These issues have been raised by the Monitoring and Registration Group, and some Review…
Poster A provisional model for when to update systematic reviews
2006 Dublin
Moher, Eccles, Grimshaw, Garritty, Sampson, Tsertsvadze
Background: As the number of systematic reviews increases, investment in empirical updating methodology research is becoming imperative. Updating systematic reviews is multi-factorial yet no model exists as to how to move the process forward.
Objectives: To present an overview of a proposed…
Poster A sensitive MEDLINE search strategy to retrieve studies of diagnostic imaging test performance
2006 Dublin
Astin, Brazzelli, Fraser, Counsell, Needham, Grimshaw
Background: Search strategies to identify randomized controlled trials are well established. However, strategies to retrieve diagnostic studies from the literature are less well developed.
Objectives: To develop a sensitive search strategy for MEDLINE to retrieve studies of diagnostic test…
Poster A simultaneous comparison of multiple pharmacological treatments for bipolar disorder: an application of Bayesian statistical methods
2006 Dublin
Bravo Vergel, Dunn, Asseburg, Beynon, Woolacott, Soares-Weiser, Geddes, Gilbody
Background: Bipolar I disorder is a severe and recurrent mood disorder associated with high morbidity and mortality. A number of pharmacological interventions have been evaluated for the prevention of relapse. Previous systematic reviews have focused on pairwise, direct comparisons of treatments,…
Poster A systematic approach to choosing outcome measures for meta-analyses of healthcare interventions
2006 Dublin
Ipser, Stein
Background: One of the difficulties in synthesising data in meta-analyses of healthcare interventions is choosing between the multitude of outcome scales which are used in clinical trials. Traditional approaches to estimating treatment effects are not ideal, involving as they do either the ad hoc…
Poster A systematic review of appraisal tools for clinical practice guidelines: multiple similarities and one common deficit
2006 Dublin
Vlayen, Aertgeerts, Hannes, Sermeus, Ramaekers
Background: One way to implement clinical practice guidelines into daily practice are clinical pathways. Unlike clinical practice guidelines, no (validated) instrument exists to assess the methodological quality of clinical pathways. A possible strategy to develop a critical appraisal tool for…
Poster Access to electronic health knowledge in five countries in Africa: a descriptive study in postgraduate doctors
2006 Dublin
Smith, Bukirwa, Mukasa, Adeh-Nsoh, Mbuyita, Honorati, Orji, Garner
Background: Electronic access in sub-Saharan Africa is improving, but subscriptions to electronic medical journals are expensive. The Health InterNetwork Access to Research Initiative (HINARI) is a World Health Organization initiative to allow free access. We conducted the first formal evaluation…
Poster Adjusting for publication bias in meta-analysis
2006 Dublin
Moreno, Sutton, Ades, Abrams, Peters, Cooper
Background: Publication bias (PB) is known to be a threat to the validity of meta-analysis (MA) that may consequently lead to incorrect decisions in health policy. A new Bayesian approach that adjusts for PB is proposed and results compared with existing methods.
Objectives: The purpose of this…
Poster Advancement of the methodological quality through a measurement tool to assess reviews: AMSTAR
2006 Dublin
Shea, Grimshaw, Wells, Boers, Hamel, Porter, Moher, Tugwell, Bouter
Background: The objective was to develop a user-friendly tool to assess the methodological quality of systematic reviews, building upon previous tools and expert consensus.
Methods: A 37-item assessment tool to measure the quality of systematic reviews was formed by combining 1) the enhanced…
Poster African randomized controlled trials - too hard to find?
2006 Dublin
Siegfried, Busgeeth, Clarke, Pienaar, Volmink
Background: A Cochrane methodology review found that handsearching journals not indexed in MEDLINE, in particular those published in languages other than English, can be a valuable way to identify randomized controlled trials (RCTs) of healthcare interventions.
Objectives: We sought medical…
Poster Agreement between systematic reviews (SRs) and clinical practice guidelines (CPGs) on drug treatment in acute stroke
2006 Dublin
José Martinez-Zapata, Urrutia, Gutierrez-Ibarluzea, Moniche, Ciapponi, Bonfill
Background: Clinical practice guidelines (CPGs) could improve clinical practice and should include systematic reviews (SRs) as their main ingredients in order to be evidence based.
Objectives: To assess the degree of concordance of the conclusions of all SRs available on acute ischaemic stroke…
Poster An assessment of the performance of meta-analytical methods for pooling intervention effects based on continuous data
2006 Dublin
McKenzie, Deeks, Green
Background: When pooling intervention effects calculated from continuous data, review authors will commonly encounter estimates of intervention effect calculated from a variety of methods, a small number of randomized controlled trials (RCTs) with some or all including few participants,…
Poster Applicability of Cochrane reviews in a developing country setting- a pilot study
2006 Dublin
Mathew, Mathew, Singh
Background: Cochrane reviews are the best resource for evidence concerning clinical interventions; however most reviews are generated by and for people in developed countries.
Objectives: To assess the applicability of Cochrane reviews in a developing country setting.
Methods: Respiratory…
Poster Approaches to interim analysis of randomized clinical trials in cancer: a survey from the Italian National Monitoring Centre for Clinical Trials
2006 Dublin
Floriani, Torri, Rotmensz, Albertazzi, Tomino, Martini, de Rosa, de Braud, Moja
Background: Several important questions have been raised about the decision to stop a randomized trial early and on what basis to reach such a decision, particularly in treatment trials in chronic life-threatening diseases, like cancer. A range of formal statistical approaches can be used as a…
Poster Are we listening to QUOROM (Quality of Reporting of Meta-analyses)? An evaluation of journal-published oral health systematic reviews
2006 Dublin
Turley, Sander
Background: The Oral Health Specialist Library, a specialist website within the National Library for Health, methodically identifies, appraises and summarises research to provide rapid access to the best available evidence for use in oral health care. During assessment of oral health systematic…
Poster Assessing healthcare interventions along the complex-simple continuum: a proposal
2006 Dublin
Lewin, Oxman, Glenton
Background: Healthcare interventions fall along a spectrum from simple to highly complex. There is growing interest in the design and evaluation of so-called complex interventions, but little work has been conducted on how intervention complexity might be conceptualised or assessed.
Objectives: To…