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Displaying 1 - 20 of 612 Index
Oral 20 ways to move Cochrane evidence into practice: a celebration of 20 years of disseminating Cochrane’s research to the world—and how you can use what we’ve done!
2013 Québec City
Thomson, Mahan, Pearson, Wieland
Background: Cochrane Fields are the Collaboration’s KT experts, employing a range of strategies to get Cochrane evidence used in practice and policy decisions. We customise our strategies based on the patient population (e.g. children), type of health care professional (e.g. nurses) and/or the type…
Oral A Bayesian approach facilitates interpretation of results in meta-analysis: the example of periodontal disease
2013 Québec City
Brignardello-Petersen, Carrasco-Labra, Pintor, Ulloa, Tomlinson
Background: Systematic reviews and meta-analysis about the treatment for periodontal disease have demonstrated statistically significant benefits of antibiotics as adjuvant therapy. However, the magnitude of the treatment effect has a clinical significance that is questionable. In this context, the…
Poster A PRISMA assessment of the reporting quality of systematic reviews or meta-analysis of interventions on diabetic nephropathy
2013 Québec City
An, Ge, Liu, Xu, Liang, Ma, Wang, Shi, Tian
Background: Diabetes prevalence has increased worldwide. Diabetic nephropathy (DN) is a common complication in diabetes and a crucial issue of public health. More and more Systematic Reviews (SRs) and Meta-analyses(MAs) on DN with different angles and opinions are emerging published these years.…
Poster A QQAQ assessment of the methodological quality of systematic reviews of China health policy
2013 Québec City
Zhao, He, Zhang, Tian
Background: More and more systematic reviews(SR) of China health policy have been published in Chinese and English journals recent years, which is very import for the health policy makers to make the right decision.
Objectives: To evaluate the methodological quality of SRs of China health…
Poster A case study on the reporting of effect size estimates in breast cancer trials
2013 Québec City
Wilson, Ghersi, Askie
Background: Guidance on trial reporting from the CONSORT statement outlines that primary and secondary outcomes should be presented with estimated effect sizes and range (item 17; [1]). In oncology trial reports, time-to-event outcomes are commonly reported in the form of survival curves. When…
Oral A cloud computing database for data extraction in a Cochrane Review
2013 Québec City
Stordal, Kapros, Busschots, Lawlor, Doherty, Smith, Hennessy, O’Mathúna
Background: An online database was needed for the Cochrane Review ‘Taxanes for the treatment of platinum pre-treated epithelial ovarian cancer’ for several reasons. Firstly, a large amount of clinical parameters were to be extracted from 68 identified studies and the data was to be subdivided into…
Oral A cloud computing database for data extraction in a Cochrane Review
2013 Québec City
Stordal, Kapros, Busschots, Lawlor, Doherty, Smith, Hennessy, O’Mathúna
Background: An online database was needed for the Cochrane Review ‘Taxanes for the treatment of platinum pre-treated epithelial ovarian cancer’ for several reasons. Firstly, a large amount of clinical parameters were to be extracted from 68 identified studies and the data was to be subdivided into…
Poster A crib sheet for Cochrane Review authors’ use of trial registries
2013 Québec City
Abrams, Pienaar, Kredo
Background: Clinical trial registries offer free, useful tools for identifying ongoing trials to be included in updates of reviews, assessing topics where reviews should be undertaken, and as a networking tool for review authors seeking further information or unpublished research. Prospective trial…
Oral A discussion of the challenges in conducting a systematic review of adverse effects including randomized trials and non-randomized studies
2013 Québec City
Furlan, Irvin, Carnide, Munhall, Loke, Marin
Objectives: To discuss the challenges faced by reviewers conducting a systematic review of adverse effects of a pharmacological intervention, and the solutions to each of these challenges that our team used in conducting a review for the Cochrane Back Review.
Results: We will use the example of…
Poster A family of different dissemination products from one Cochrane Review
2013 Québec City
Rosenbaum, Glenton, Lewin
Background and Objectives: For several years, the Norwegian Cochrane branch and the Norwegian EPOC satellite have participated in the development of dissemination products derived from systematic reviews, aimed at audiences using evidence for different tasks. All products use the Summary of…
Oral A framework for individual participant data meta-analysis in the presence of missing data
2013 Québec City
Debray, Koffijberg, Jolani, Van Buuren, Moons
Background: Individual participant data meta-analyses (IPD-MA) are an increasingly popular approach for developing multivariable risk prediction models. Recently, a framework was proposed to develop, implement and validate such models when baseline risks are heterogeneous across studies. Because…
Poster A framework to identifying and characterise research gaps from systematic reviews
2013 Québec City
Robinson
Background: Research gaps prevent systematic reviewers from making conclusions and, ultimately, limit our ability to make informed health care decisions. Methods for conducting a systematic review are well-defined but there has been no explicit process for the identification of research gaps from…
Oral A framework to interpret external validition studies of prediction models
2013 Québec City
Debray, Koffijberg, Vergouwe, Nieboer, Moons, Steyerberg
Background: It is widely acknowledged that newly developed diagnostic or prognostic prediction models should be externally validated to assess their performance. It is recommended to test the model in ‘different but related’ subjects, but criteria for ‘different but related’ are lacking.…
Poster A hybrid approach for automating citation screening process
2013 Québec City
Zhang, Lei, Robinson
Background: Building a classificationmethod to facilitate screening of search results is an explicit way to enable more efficiency in systematic review process. We propose to use a hybrid approach to optimize the collection of features used to characterize the citations (feature space) by combining…
Poster A novel approach to presenting adverse effect Results: a case study
2013 Québec City
Dryden, Sumamo Schellenberg, Vandermeer, Rowe
Background: We conducted a systematic review of randomized controlled trials (RCTs) on the comparative effectiveness and safety of drugs for acute migraine headache in the emergency department. Safety is poorly reported and often the same adverse effects (AEs) are not reported for similar…
Poster A numbers of randomized controlled trials reported in Chinese literature are not covered in MEDLINE
2013 Québec City
Zhang, Wang, Lei, Yang
Background: More and more randomized controlled trials(RCTs) have been published in Chinese journals; However, Language restriction can be a problem for English-speaking countries collecting the relevant research data when they conduct systematic reviews.
Objectives: To the aim of this survey…
Poster A practical taxonomy proposal for systematic reviews of therapeutic interventions
2013 Québec City
Bender, Lerch
Background: No consistently used terminology is currently available to classify systematic reviews of therapeutic interventions according to their aim, their methodological rigor and the conclusiveness of their results. Some researchers consider systematic reviews to be merely observational studies…
Poster A review of online evidence-based practice point-of-care information summary providers: an update
2013 Québec City
Moja, Gonzalez Lorenzo, Tagliabue, Banzi
Background: Reliable information to solve clinical doubts at the point-of-care is a pillar of modern practice. In 2008, a previous study assessing online evidence-based practice (EBP) point-of-care summaries showed that most products were deficient in respect to at least one dimension in breadth,…
Oral A selection model to explore whether publication bias is more likely in two-arm and placebo-controlled trials rather than in multi-arm and head-to-head studies
2013 Québec City
Mavridis, Welton, Sutton, Salanti
Background: Selection models are used to explore the potential impact of publication bias (PB) via sensitivity analysis by making assumptions for the probability of publication of trials conditional on their precision. Selection models have been previously extended for a star-shaped network where…
Oral A simple adaptation considerably improves the performance of the standard method for random effects meta-analysis
2013 Québec City
IntHout, Ioannidis, Borm
Background: The DerSimonian and Laird approach (DL) is widely used for random effects meta-analysis, but this often results in inappropriate type I error rates. The method described by Sidik and Jonkman (SJ) is known to perform better when trials of similar size are combined. However evidence in…