Background: Evidence on practices to improve patient safety is growing, but systematic reviews about the effects of these interventions are lacking. The Spanish National Health Service Quality Agency commissioned the Iberoamerican Cochrane Centre to create a database of systematic reviews about topics related specifically to patient safety to facilitate clinicians accessing evidence to inform decision-making. Objectives: To build a database of systematic reviews about the effects of interventions related to relevant issues on patient safety. Methods: We identified systematic reviews through: i) relevant institutions and agencies in the field of healthcare quality and safety (e.g. National Quality Forum, NHS National Patient Safety Agency, etc.); ii) weekly searches in PubMed; and iii) handsearch of the Cochrane Database of Systematic Reviews. We considered eligible reviews if included interventions aimed to avoid outcomes caused by healthcare management rather than by the patient’s underlying disease. Each of the eligible reviews was entered in a register created with ProCite, and labelled depending on the clinical specialty and the main outcomes assessed following the criteria of WHO’s World Alliance for Patient Safety. Results: We have identified 337 systematic reviews relevant for patient safety up to now, 20% of which are Cochrane reviews. Most of them are focused in gynaecologic and perinatal care, surgery, nursing, changes in healthcare organizations, and critical care. Regarding the outcomes addressed, the vast majority of reviews assessed the impact of different strategies in the rate of healthcare associated infections or medical errors, followed by adverse events due to the healthcare professionals’ performance (e.g. surgical errors, misuse of medical products or devices, etc.). Conclusions: Registering and indexing these systematic reviews in a unique database will provide healthcare professionals interested in patient safety simple access to reliable evidence that will make the decision making process easier in issues related to healthcare quality and safety.