Background: The Cochrane Effective Practice and Organization of Care (EPOC) Group currently updates an overview of systematic reviews (SRs) assessing interventions targeting professional behaviours. A major component of this project is to search for and conduct quality assessments of existing systematic reviews. There has been an increase in the number of SRs published over the years on professional behaviour change interventions; however, the quality of these reviews are variable and multiple reviews are often published addressing similar interventions which results in a redundancy of literature and duplication of efforts by reviewers. Objectives: To identify systematic reviews of health professional behaviour change interventions. To examine their epidemiology, methodological quality and descriptive characteristics of the identified reviews. Methods: SRs were identified from 1966 to 2008 from MEDLINE, Cochrane Database of Systematic Reviews, EMBASE and DARE. Reviews were assessed if they evaluated a professional intervention, according to the EPOC taxonomy. Quality of each SR was assessed using ‘A Measurement Tool to Assess Systematic Reviews’ (AMSTAR). Results: Over 200 reviews were identified and 80 were published between 2006 and 2008. The majority of SRs were published in the USA, UK and Canada. Of the SRs published since 2006, 40% were classified as low quality, 50% as moderate quality and 10% as high quality. Conclusions: There continues to be many new reviews published evaluating professional behaviour change strategies; however, the overall quality of these reviews is less than adequate. Authors of professional behaviour change reviews need to consider the current body of evidence and address the quality and methods of their reviews when planning SRs in this area. This work is being done as part of the www.rxforchange.ca website of the Canadian Agency for Drugs and Technologies in Health (CADTH).