Background: Neurally mediated reflex syncope is by far the most common cause of transient loss of consciousness. Based on pathophysiology, neurally mediated reflex syncope is subdivided into several subtypes including vasovagal syncope, carotid sinus syncope and situational syncope. For these subdiagnoses we investigated the effectiveness of both pharmacological and dual chamber pacemaker treatment for 10 different outcome measures. Methods: We classified the treatment effects of included studies at three levels: 1) subtype of neurally mediated reflex syncope; 2) pharmacological or pacemaker treatment modality; and 3) treatment comparison. Next, we calculated summary estimates of treatment effect (with 95% confidence intervals) for each outcome measure provided that study data were available for a particular treatment comparison. We represented treatment effects of individual studies in additional tables categorized by treatment comparison and subdiagnosis of neurally mediated reflex syncope. In ‘Summary of findings’ tables we only represented combined treatment effects of studies comparing pharmacological or pacemaker treatment with conventional standard treatment or placebo treatment. In order to maintain comprehensiveness, we did not make GRADE profiles. Results: We included 46 studies in our review. Of these, 40 were on vasovagal syncope, 6 on carotid sinus syncope and none on situational syncope. No consistent significant differences were observed with respect to outcomes obtained during clinical follow-up in any of the placebo-controlled pharmacological and pacemaker interventions for vasovagal syncope and carotid sinus syncope. Conclusions: Comprehensiveness of large Cochrane reviews is enhanced by categorization of different studies by disease entity, treatment modality and treatment comparison. In addition, limitation of ‘Summary of findings’ tables to the most relevant treatment comparisons also enhances comprehensiveness.