Background: For evidence users it has become impractical to answer specific questions by reading primary studies. The increasing amount of information is difficult to manage and what is obtained is prone to publication bias. Systematic reviews can provide an unbiased synthesis of existing evidence, so they have become key to assist clinical decisions. At present there are many reviews answering similar questions. We know Cochrane s are more rigorous than other reviews, but we have little information about what is the proportion of evidence actually covered by Cochrane reviews. Objectives: To compare the coverage of Cochrane vs non-Cochrane reviews of the therapeutic evidence in a specific clinical condition. Methods EPISTEMONIKOS is a database in development that will provide access to the included studies of systematic reviews for a similar question. This study is part of the first scoping review created for this project. We selected the topic prevention and treatment of thromboembolic disease because of its relevance for several specialties and the variety of interventions in this area. So, many existing studies and reviews were anticipated. Our study considers the following steps: 1) MEDLINE search using a hedge for reviews with emphasis in specificity; 2) Selection of articles intending to systematically synthesize evidence; 3) Extraction of all randomized trials included in those reviews; 4) Description of each study and classification into a clinical question framework; 5) Calculation of the coverage of Cochrane reviews (percentage of studies included in Cochrane reviews); 5) Studies not covered will be classified as: question not covered by any Cochrane review, study publicated after search date of corresponding review, excluded study, study missed by the Cochrane review). Results and conclusions: 217 reviews have already been identified. The search (updated monthly) will be last updated on September 30. Results and conclusions will be presented at the Colloquium.