Background: Cochrane Pregnancy and Childbirth Group (PCG) Reviews have a potential inherent conflict between maternal and infant outcomes. Interventions may be beneficial to the mother but not the infant and vice-versa.

Objectives: The objective is to determine what factors influence overall conclusions in PCG Reviews where interventions have different effects on maternal and infant outcomes.

Methods: All current PCG Cochrane Reviews will be reviewed and primary outcomes will be extracted and categorized into maternal and infant groups. Other factors, such as the profession of the authors (such as obstetrician vs. pediatrician), will also be extracted. The results of the reviews regarding benefits or harms for primary maternal and infant outcomes will be extracted and Reviews for which there are benefits for one group and harms or potential harms for the other group will be analyzed. The overall conclusions will be categorized by whether they follow the benefit or harm for one group or are inconclusive due to the discrepancy. Other factors about the review will be analyzed in an attempt to ascertain any bias or factors leading to the overall conclusions. Secondary outcomes will be reviewed only if either maternal or infant outcomes are not represented in primary outcomes.

Results: There are 469 current PCG Cochrane Reviews. The data extraction is currently ongoing. All data extraction and analysis will be completed before the Colloquium.

Conclusions: Pending at this time regarding potential biases in summary conclusions of PCG Reviews when maternal and infant outcomes are differing.