Meta-analysis of patient-reported outcomes and application of minimal important differences to facilitate interpretation in systematic reviews and guideline development

Article type
Authors
Devji T1, Carrasco-Labra A1, Guyatt G2, Patrick D3, Johnston B4, Nesrallah G5
1McMaster University
2McMaster
3University of Washington
4The Hospital for Sick Children
5Humber River Regional Hospital
Abstract
Objectives:
1) Present and apply principles influencing choice of patient-reported outcome measures (PROMs) in systematic reviews.
2) Review the use of minimally important differences (MIDs) in enhancing interpretability of PROMs in systematic reviews.
3) Introduce an instrument for evaluating the credibility of MIDs and apply it to a sample of studies.
4) Help participants apply presentation approaches relying on the MID to make PROMs more interpretable in systematic reviews.

Description:
This workshop will build on a workshop presented earlier at the Summit describing approaches to make PROMs more interpretable in systematic reviews, including those relying on MIDs. This workshop will review the principles governing choice of an outcome measure in systematic reviews. Participants will apply the approach to a data set. Then we will review the concept of the MID and its application to enhance interpretability of reviews. We will then introduce an instrument for evaluating the credibility of MIDs in PROMs and participants will apply the instrument to a data set. Finally, participants will apply the methods for using the MID to enhance interpretability to a data set to generate results in MID units, relative effects, and risk differences.