Are retracted studies affecting our reviews?

Tags: Poster
Pardo Pardo J1, Harbin S2, Welch V3
1Cochrane Musculoskeletal, 2Cochrane Back and Neck, 3Campbell Collaboration


Although most of the scientific literature is sound, there are cases of fraud in the scientific arena. Retraction is the mechanism used by publishers to indicate that a study is problematic.


To assess how Campbell and Cochrane Reviews have dealt with retracted studies, and to calculate the prevalence of retracted studies in the Cochrane Database of Systematic Reviews.


We searched the Cochrane Library through the Wiley interface, looking for the word "retraction" in the full text of the review. We searched full text of Campbell reviews by using the site restricted search in Google. To calculate the prevalence of retractions, we used the function “included in review” and “in Medline” of the Cochrane Register of Studies on-line, retrieve the unique identifiers for each study and crossed them with "Retracted Publication" heading on Publication Type.


For Cochrane Reviews, 37 reviews have identified retracted studies, and including a total of 63 retracted studies. Thirty-four reviews excluded the retracted studies, noting this in the table of excluded studies. Of the 37 reviews, 70% had only one study retracted. The range of retractions went from one to nine. Two reviews attempted sensitivity analysis to assess the impact the retracted studies would have had, if included. Of the three reviews that included retracted studies, one noted the retraction and announced that the study would be withdrawn in a future update. The other two considered that the reasons for retraction of the studies did not invalidate the data, and decided to include the study.

For Campbell reviews, no reviews had mentioned retracted studies.

For the prevalence of retracted studies, a preliminary search limited to one Cochrane Group shows it affects a minority of all included studies: only 0.0025% (4/1625) are retracted studies.


Retracted studies are an infrequent problem, but they appear often enough to potentially influence the results of some Cochrane Reviews. A simple exclusion of retracted studies might lead to publication bias. Careful consideration of the exclusion of the studies is needed, and to evaluate the impact that any decision could have in the results of the review in a sensitivity analysis.

Patient or healthcare consumer involvement:

No patients were involved in developing this project.