Prioritization of primary research based on a mixed-methods systematic review

Article type
Authors
Dockx K1, Van Remoortel H1, Vande Veegaete A1, De Buck E2, Vandekerckhove P3
1Centre for Evidence-Based Practice, Belgian Red Cross
2Centre for Evidence-Based Practice, Belgian Red Cross, Department of Public Health and Primary Care, Faculty of Medicine, KU Leuven
3Belgian Red Cross, Department of Public Health and Primary Care, Faculty of Medicine, KU Leuven; Faculty of Medicine and Health Sciences, Ghent University
Abstract
Background: The Belgian Red Cross (BRC) uses systematic reviews (SRs) to:
1) achieve an evidence-based substantiation of its activities; 2) identify relevant knowledge gaps; and 3) fill gaps by setting up primary research.
One of these gaps concerns the effect of hand washing and sanitation (HW&S) promotion programs to induce behavior change in low- and middle-income countries (LMIC), for which a mixed-methods SR (MMSR) was conducted.

Objectives: To use a MMSR to: 1) identify knowledge gaps concerning HW&S promotion programs; 2) design a primary field study.

Methods: The MMSR studied: 1) the effectiveness of HW&S promotional programs, and 2) factors influencing their implementation. The primary outcome was HW&S behavior change, which was subdivided into uptake (during implementation), adherence (≤ 12 months follow-up ) or longer-term use (> 12 months follow-up). Knowledge gaps were defined as topics for which ≤ 1 study was identified, or when the available evidence was of very low quality. These gaps were discussed with a group of stakeholders with HW&S field experience. A balance was made between gaps in evidence and operational context and needs.

Results: The MMSR identified 42 quantitative and 28 qualitative studies. Figure 1 shows the available HW&S evidence and the identified knowledge gaps (in grey). The MMSR showed that: 1) HW&S promotional programs can be effective, 2) a single most effective program could not be identified and a combination of different promotional elements is probably the most effective strategy. We identified several barriers and facilitators for implementation i.e. using short communication messages. Following a stakeholder discussion, BRC decided to design a primary field study, investigating the effectiveness of a community-based (CB) program versus a combined intervention, i.e. CB + theory-based, on HW&S behavior during uptake and adherence in Tanzania. By incorporating identified barriers and facilitators in the design of the study, effectiveness of the intervention may increase.

Conclusions: Quantitative and qualitative input from a MMSR can be useful to identify knowledge gaps and to inform the design of a primary field study.

Patient or healthcare consumer involvement: The MMSR and the primary study take into account the needs of people from LMIC by closely working with stakeholders with field experience.